Roberto Chignola

Roberto Chignola,  July 9, 2014
Position
Assistant Professor
Role
Ricercatore
Academic sector
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Office
Ca' Vignal 1,  Floor 2,  Room 5
Telephone
045 802 7953
Fax
045 802 7929
E-mail
roberto|chignola*univr|it <== Replace | with . and * with @ to have the right email address.
Personal web page
http://profs.sci.univr.it/~chignola

Office Hours

Thursday, Hours 10:00 AM - 12:30 PM,  
Il dott. Roberto Chignola è disponibile a ricevere gli studenti anche al di fuori del giorno e dell'orario di ricevimento. 

Curriculum

Il dott. Roberto Chignola svolge prevalentemente ricerche nel campo dell'oncologia sperimentale e teorica. In particolare è interessato ai molteplici aspetti biologici e biofisici della crescita dei tumori solidi anche in relazione agli effetti delle terapie. Integra l'attività sperimentale, che viene svolta nel laboratorio di cui è responsabile, con lo sviluppo di modelli matematici in grado di descrivere il comportamento di reti molecolari, singole cellule e popolazioni cellulari, nell'ottica di un approccio quantitativo alla comprensione del comportamento dei tumori. In particolare è in grado di tradurre modelli matematici in esperimenti e viceversa. Collabora con i colleghi mettendo a disposizione le sue competenze nel campo dela statistica, e le sue competenze sperimentali nel campo delle colture di cellule umane (colture tradizionali, colture di sferoidi, colture di cellule differenziate, ecc.). Ha interessi scientifici nel campo della geologia, ed in particolare studia fenomeni paleocarsici presenti nel territorio in collaborazione con geologi esperti. 

Dr. Roberto Chignola is a researcher in the field of experimental and theoretical oncology. In particular, his interests concern the biological and biophysical properties of solid tumours that are related to tumour growth and response to therapies. The experimental work, that is carried out in his lab, proceeds in parallel with the development of mathematical models describing the behaviour of molecules, cells and organisms. Emphasis is therefore given to the quantitative approach to biological and biomedical problems. Indeed, he has a long standing experience in the translation of model equations into lab experiments and vice versa. His skills in statistics, as well as in human cell culture (traditional cultures, spheroids, differentiated cells, etc.), are shared with colleagues from different scientific fields. He has some interests in geology, and in particular he studies paleokarst caves in collaboration with expert geologists.

Modules

Modules running in the period selected: 20.
Click on the module to see the timetable and course details.

Course Name Total credits Online Teacher credits Modules offered by this teacher
Bachelor's degree in Biotechnology Mathematics and statistics (2017/2018)   12  eLearning (Statistica)
Bachelor's degree in Applied Mathematics Mathematical models in biology (2016/2017)   6   
Bachelor's degree in Biotechnology Mathematics and statistics (2016/2017)   12  eLearning (Statistica)
Bachelor's degree in Biotechnology Mathematics and statistics (2015/2016)   12  eLearning (Statistica)
Bachelor's degree in Biotechnology Introduction to Pathology and Immunology (2012/2013)   6   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Cellular Culture Techniques (2009/2010)   6    MOD. CELLULE ANIMALI (TEORIA)
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2009/2010)   4   
Masters in Molecular and Industrial Biotechniques Pathology and oncology (2009/2010)   2   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Cellular Culture Techniques (2008/2009)   6    Mod. cellule animali (teoria)
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2008/2009)   4   
Masters in Molecular and Industrial Biotechniques Pathology and oncology (2008/2009)   2   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Cellular Culture Techniques (2007/2008)   6    Mod. cellule animali (teoria)
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2007/2008)   4   
Masters in Molecular and Industrial Biotechniques Pathology and oncology (2007/2008)   2   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Cellular Culture Techniques (2004/2005)   6      modulo animale
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2004/2005)   4     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2003/2004)   4     
Bachelor in Agroindustrial Biotechnology (old system) Immunology (2003/2004)   60     
Bachelor in Agroindustrial Biotechnology (old system) Immunology (2002/2003)   0     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Immunology (2002/2003)   5     

 

Research groups

Immunologia e oncologia teorica sperimentale
Responsabile: dott. Roberto Chignola – Referente sicurezza: Roberto Chignola
Theoretical and Experimental Oncology
Skills
Topic Description Research area
biophysics and biomedicine During the last 16 years I have been collaborating with Prof. Edoardo Milotti (Department of Physics, University of Trieste) and his reaserch group to the development of a numerical model for the growth of solid tumors. The project, which is now in an advanced stage of development, has allowed us to deepen our understanding of the following biophysical/biological aspects: cell cycle desynchronisation dynamics, how biochemical thresholds that govern cell cycle dynamics work, the behaviour of cell aggregates and the onset of emerging collective properties. The results have then been used to synthesize a new metabolic scaling law for tumours and more recently to detail the diffusion of small molecules in the tumour microenvironment. Our multidisciplinary approach is rigoroulsy quantitative, and in these years it has also stimulated new lab work and experimental strategies. Biophysics - Biophysics
Projects
Title Starting date
Slowing down the aggressiveness of solid tumors 3/1/17
Simulazione numerica di Sferoidi Tumorali Multicellulari: validazione sperimentale, stima di parametri e modellizzazione di specifici circuiti biochimici 10/17/11
Messa punto di nuove strategie per lo sviluppo di vaccini per il trattamento dell’allergia al frumento 6/1/11
Nuove tecnologie per il made in Italy 8/1/10
Virtual Biophysics Lab (VBL-RAD) 1/1/09
Simulazione numerica di popolazioni di cellule tumorali: verifica sperimentale, stima dei parametri e analisi critica delle previsioni 7/29/08
Realizzazione e validazione sperimentale di un modello numerico di crescita di sferoidi tumorali 10/30/05
Crescita di sferoidi tumorali: simulazione numerica e validazione sperimentale del modello 10/1/05
Interrelazione tra sistema immunitario e microambiente tissutale in un modello tumorale 5/1/04
Studio della crescita di aggregati di cellule tumorali 4/1/04
Individuazione di nuovi fattori di rischio nel diabete giovanile insulino dipendente, nella celiachia e nei soggetti con doppio difetto. 9/29/99





Roberto Chignola
Office Collegial Body
Teachers' Committee in the Master in Applied Biotechnology - Department Biotechnology
componente L2 Collegio Didattico di Biotecnologie - Department Biotechnology
researcher Scientific and Technological Department Council - Department Biotechnology
component Scientific and Technological Department Council
Consiglio del Dipartimento di Medicina - Department Medicine
member Consiglio della Scuola di dottorato di "Scienze Ingegneria Medicina"
component Scientific and Technological Department Board