Massimo Delledonne

Foto MD,  September 12, 2012
Position
Full Professor
Role
Prof. Ordinario
Academic sector
BIO/18 - GENETICS
Research sector (ERC)
LS2_1 - Genomics, comparative genomics, functional genomics

Office
Ca' Vignal 1,  Floor 2,  Room 21
Telephone
045 802 7962; Lab: 045 802 7058
Fax
045 802 7929
E-mail
massimo|delledonne*univr|it <== Replace | with . and * with @ to have the right email address.
Personal web page
http://profs.scienze.univr.it/delledonne/

Office Hours

Si receve previo appuntamento

Curriculum

Modules

Modules running in the period selected: 53.
Click on the module to see the timetable and course details.

Course Name Total credits Online Teacher credits Modules offered by this teacher
Bachelor's degree in Biotechnology Genetics (2017/2018)   6   
Master's degree in Molecular and Medical Biotechnology Human genome sequencing and interpretation (2017/2018)   6   
Bachelor's degree in Biotechnology Genetics (2016/2017)   6   
Master's degree in Molecular and Medical Biotechnology Human genome sequencing and interpretation (2016/2017)   6   
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2016/2017)   6  eLearning (a)
Bachelor's degree in Biotechnology Genetics (2015/2016)   6   
Master's degree in Molecular and Medical Biotechnology Human genome sequencing and interpretation (2015/2016)   6   
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2015/2016)   6    (a)
Bachelor's degree in Biotechnology Genetics (2014/2015)   6   
Master's degree in Bioinformatics and Medical Biotechnology Genomes (2014/2015)   12    STRUTTURA E FUNZIONE DEI GENOMI (Teoria 1)
STRUTTURA E FUNZIONE DEI GENOMI (Teoria 2)
Master's degree in Agri-Food Biotechnology Structure and function of genomes (2014/2015)   6    (Teoria 2)
Bachelor's degree in Biotechnology Genetics (2013/2014)   6   
Master's degree in Agri-Food Biotechnology Structure and function of genomes (2013/2014)   6   
Bachelor's degree in Biotechnology Genetics (2012/2013)   6   
Master's degree in Bioinformatics and Medical Biotechnology Genomica e trascrittomica (2012/2013)   6   
Bachelor's degree in Biotechnology Genetics (2011/2012)   6   
Master's degree in Agri-Food Biotechnology Structure and function of genomes (2011/2012)   6    (Parte 2)
Master's degree in Bioinformatics and Medical Biotechnology Genomica e trascrittomica (2011/2012)   6    (Parte 1)
(Parte 2)
Bachelor's degree in Biotechnology Genetics (2010/2011)   6   
Master's degree in Bioinformatics and Medical Biotechnology Genomica e trascrittomica (2010/2011)   6   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2009/2010)   8    (Teoria)
Bachelor's degree in Biotechnology Genetics (2009/2010)   6   
Master's degree in Agri-Food Biotechnology Genome structure and function (2009/2010)   12    STRUTTURA E FUNZIONE DEI GENOMI(I)
Bachelor's degree in Bioinformatics (until 2008-2009) Basis of genetics (2008/2009)   5   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2008/2009)   8    Modulo 1 - Teoria
Modulo 1 - Laboratorio
Masters in Agroindustrial Biotechnology Genetic biotechnology (2008/2009)   5    Teoria
Laboratorio
Bachelor's degree in Bioinformatics (until 2008-2009) Basis of genetics (2007/2008)   5   
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2007/2008)   8    laboratorio (modulo 1)
teoria (modulo 1)
Masters in Agroindustrial Biotechnology Genetic biotechnology (2007/2008)   5    Laboratorio
Teoria
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2006/2007)   8    Mod. 1 teoria
Mod. 1 laboratorio
Masters in Agroindustrial Biotechnology Genetic biotechnology (2006/2007)   5    Teoria
Laboratorio
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2005/2006)   8    Teoria
Laboratorio
Masters in Agroindustrial Biotechnology Genetic biotechnology (2005/2006)   5    Teoria
Laboratorio
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2004/2005)   8      1° modulo
Masters in Agroindustrial Biotechnology Genetic biotechnology (2004/2005)   5     
Bachelor in Agroindustrial Biotechnology (old system) Genetic biotechnology (2004/2005)   0     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2003/2004)   8     
Masters in Agroindustrial Biotechnology Genetic biotechnology (2003/2004)   4     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biomolecular Technology (2002/2003)   8     
Bachelor in Agroindustrial Biotechnology (old system) Genetic Biotechnology (2002/2003)   150     
Bachelor in Agroindustrial Biotechnology (old system) Genetic Biotechnology (2001/2002)   150     
Bachelor in Agroindustrial Biotechnology (old system) Genetic Biotechnology (2000/2001)   150     
Bachelor in Agroindustrial Biotechnology (old system) Genetic Biotechnology (1999/2000)   150     

Advanced teaching activities
Name Online
Corso “Metodologie avanzate in analisi trascrittomica, proteomica, metabolomica e metodologie biochimiche“ (22° ciclo - PhD Program in Applied Biotechnologies)
 
Skills
Topic Description Research area
Laboratorio di Biotecnologie genetiche My laboratory specialises in the characterization of NO functions at cellular and molecular levels in plants. In collaboration with Chris Lamb we made pioneering work towards the discovery of NO function during the plant hypersensitive disease resistance response. We found that during the hypersensitive response plant cells accumulate NO, which co-operates with reactive oxygen species in the induction of hypersensitive cell death, and functions independently of such intermediates in the induction of defence related genes (Delledonne et al., 1998). We then demonstrated that the rates of production and dismutation of O2- generated during the oxidative burst play a crucial role in the modulation and integration of NO/H2O2 signalling in the hypersensitive response (Delledonne et al., 2001). Due to the many possible mechanisms of NO action, a clear picture of its involvement in plant resistance to pathogens is far from being achieved. Our goal is to characterize and modulate the signal transduction pathways leading to the hypersensitive disease resistance response. We are going in deep in the analysis of genes involved in the hypersensitive cell death and in the establishment of disease resistance whose expression is under control of NO. We are also focusing on the mechanisms regulating NO level in plant, and on the identification and characterization of signalling mechanisms that operate downstream of NO accumulation. In particular, we are analysing the occurrence of NO-dependent posttranslational modification of proteins (S-nitrosylation) and studying the changes in the pattern of nitrosylated proteins during the plant hypersensitive disease resistance response. Identification of the proteins that are susceptible to this modification will help to understand the functional consequences and the relevance of S-nitrosylation in physiological and pathophysiological conditions. The group is now moving on NO signaling functions in grape, although Arabidopsis remains the model plant on which we will continue to work with Plant Sciences - Plant Sciences
Laboratorio di Genomica Funzionale As deep sequencing has rapidly gained popularity for transcriptome analysis because of its ability to generate digital and quantitative information on annotated genes, we are implementing mRNA-Seq for expression analysis, using Vitis vinifera as model organism. The cDNAs libraries obtained by retrotrascription of fragmented mRNA, are sequenced with an Illumina Genome Analyzer IIx. By using two different softwares for alignment of sequences on the reference genomes (ELAND and BOWTIE) the short reads (36 or 75 nucleotides, single reads or paired ends) are mapped to exons, introns or intergenic regions, hence identifying new exons or new genes not predicted. We have adapted modules of the ERANGE program for digital gene expression analysis, detection of alternative splicing (annotated or new) and SNPs discovery. A strong bioinformatics engagement was necessary to develop a modified module in ERANGE software dedicated to the alternative splicing detection. Expression values, calculated as reads per kilobase of exon model per million mapped reads (RPKM) are then used to monitor changes in gene expression. We are currently evaluating several statistical approaches to identify genes which are significantly modulated, and we are comparing their output with the results obtained on the same reference material with different microarray designs Genetics & Heredity - Genetics & Heredity
Projects
Title Starting date
Nanotecnologie nello sviluppo di molecole e di sistemi/protocolli innovativi applicati alla diagnostica delle patologie cardiovascolari 10/1/11
VERONA NANOMEDICINE INITIATIVE 10/1/11
Vigneto Valorizzazione dei Principali Vitigni Autoctoni Italiani e dei loro “Terroir” 1/1/11
Nuove tecnologie per il made in Italy 8/1/10
Dagli studi internazionali di “ Genome Wide Scan” alla validazione regionale. Iniziativa di spin-off pubblico-privato per la replicazione e la validazione clinica nella popolazione Veneta di un test personalizzato feno-genotipico per la predizione del rischio coronarico. 6/1/10
A comprehensive environmental genomic study of socially important diseases in Russia and the EU (EUROGEN) 1/1/10
Studio dei meccanismi di risposta e resistenza della pianta al perossinitrito”. Programmi di ricerca scientifica di rilevante interesse nazionale 1/1/09
Sequenziamento del genoma del pesco ed utilizzo della sequenza in programmi di miglioramento della qualità del frutto del pesco e della resistenza alle malattie 1/1/09
New sequencing technologies for structural and functional genome analysis 10/1/08
Sintesi e caratterizzazione di materiali nanostrutturati luminescenti upconverter per applicazioni in Medicina e Scienze della Vita 8/20/08
Innovative chemical and molecular methodologies for characterising the mechanisms of mineral nutrition in vine and studying the effects of fertilization and terroir on the quality of grapes and wine. 1/1/08
Completamento di un Centro di Genomica Funzionale Vegetale 1/1/08
Realizzazione di un laboratorio integrato per la sintesi e la caratterizzazione di materiali nanostrutturati luminescenti per applicazioni in medicina e scienze della vita 1/1/08
Studio dell’accumulo ossido nitrico-dipendente e segnalazione del cGMP durante l’interazione pianta-patogeno Arabidopsis thaliana (2006) 1/1/06
Costituzione di un Centro di Genomica Funzionale Vegetale 1/1/06
Analisi del proteoma S-nitrosilato di Arabidopsis thaliana 9/1/05
BACCA-Caratterizzazione del processo di maturazione e surmaturazione della bacca dei vitigni rossi veronesi” 1/1/05
VIGNA (Vitis genome analysis) Sequenziamento e Caratterizzazione funzionale del genoma di Vitis vinifera 1/1/05
Laboratorio di tecnologie elettrobiochimiche miniaturizzate per l'analisi e la ricerca. 1/1/05
Isolamento e caratterizzazione di geni regolati da ossido nitrico (NO) nell’interazione pianta-microrganismo: ruolo durante la patogenesi e simbiosi. 4/1/04
Isolamento e caratterizzazione di geni regolati da ossido nitrico (NO) nell’interazione pianta-microrganismo: ruolo durante la patogenesi e simbiosi 4/1/04
Post genomica di leguminose foraggere 11/5/02




Chairperson/Coordinator
Director
Graduate School Science, Engineering and Medicine

Massimo Delledonne
Office Collegial Body
full prof. Collegio dei Docenti del Dottorato in Biotecnologie
Teachers' Committee in the Master in Applied Biotechnology - Department Biotechnology
componente L2 - LM9 Collegio Didattico di Biotecnologie - Department Biotechnology
component Collegio Didattico di Informatica - Department Computer Science
full prof. Scientific and Technological Department Council - Department Biotechnology
component Scientific and Technological Department Council
coordinatore del corso di dottorato Natural and Engineering Sciences PhD School Council