General and Molecular Pharmacology (2011/2012)

Course not running

Course code
4S000684
Credits
6
Coordinator
Maria Enrica Fracasso
Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
FARMACOLOGIA DI BASE 1 BIO/14-PHARMACOLOGY I semestre Elisa Bertazzoni Minelli
TOSSICOLOGIA MOLECOLARE E VALUTAZIONE DEL DANNO DA FARMACI 2 BIO/14-PHARMACOLOGY See the unit page See the unit page
RILEVAMENTO REAZIONI AVVERSE DA FARMACI 2 BIO/14-PHARMACOLOGY See the unit page See the unit page
FARMACOLOGIA DI SISTEMI: RECETTORI E TRASDUZIONE DEL SEGNALE 1 BIO/14-PHARMACOLOGY I semestre Elisa Bertazzoni Minelli

Learning outcomes

Module: FARMACOLOGIA DI BASE
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General educational goals
Provide students with theoretical and practical knowledge in the field of structural biology, basic and clinical pharmacology, and toxicology, with particular reference to finalizing the development, design and characterization of drugs. Provide students with the main elements of knowledge on basic research and application in the field of drugs and more generally on the scope of biomedicine, with particular reference to the phases of drug development in the clinic setting.

Specific educational goals
At the end of the course the student should know: the processes of production and extraction of drugs; the main methods for the preparation of pharmaceutical formulations; the drug structure- activity relationship; the interactions between different receptors and pharmacological activity; the general principles of pharmacokinetics and the modifying factors; the relationship between pharmacokinetics and pharmacodynamics; the modifications of drugs pharmacodynamics and relationship with chemical structure; the phases of drug development and the main rules for the conduct of preclinical and clinical studies on drugs; the key elements that characterize the pharmaceutical market, with particular reference to the analysis of consumption of the same; the different classification of drugs for the purposes of analysis to be made; the general principles of toxicology; the main tests for toxicological analysis.
The student will be able: to determine the main pharmacokinetic parameters; to define the structure-activity relationship; to know the main and innovative method for the study and preparations of drugs; to define the difference between acute and chronic toxicology; to run the main toxicology lab tests; to use the main database on adverse drug reactions; to encode drugs and adverse reactions; to perform analysis of consumption of drugs using the defined daily doses; to define characteristic and distinctive elements of adverse drug reactions.


Module: TOSSICOLOGIA MOLECOLARE E VALUTAZIONE DEL DANNO DA FARMACI
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Module: FARMACOLOGIA DI SISTEMI: RECETTORI E TRASDUZIONE DEL SEGNALE
-------
General educational goals
Provide students with theoretical and practical knowledge in the field of structural biology, basic and clinical pharmacology, and toxicology, with particular reference to finalizing the development, design and characterization of drugs. Provide students with the main elements of knowledge on basic research and application in the field of drugs and more generally on the scope of biomedicine, with particular reference to the phases of drug development in the clinic setting.

Specific educational goals
At the end of the course the student should know: the processes of production and extraction of drugs; the main methods for the preparation of pharmaceutical formulations; the drug structure- activity relationship; the interactions between different receptors and pharmacological activity; the general principles of pharmacokinetics and the modifying factors; the relationship between pharmacokinetics and pharmacodynamics; the modifications of drugs pharmacodynamics and relationship with chemical structure; the phases of drug development and the main rules for the conduct of preclinical and clinical studies on drugs; the key elements that characterize the pharmaceutical market, with particular reference to the analysis of consumption of the same; the different classification of drugs for the purposes of analysis to be made; the general principles of toxicology; the main tests for toxicological analysis.
The student will be able: to determine the main pharmacokinetic parameters; to define the structure-activity relationship; to know the main and innovative method for the study and preparations of drugs; to define the difference between acute and chronic toxicology; to run the main toxicology lab tests; to use the main database on adverse drug reactions; to encode drugs and adverse reactions; to perform analysis of consumption of drugs using the defined daily doses; to define characteristic and distinctive elements of adverse drug reactions.


Module: RILEVAMENTO REAZIONI AVVERSE DA FARMACI
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Syllabus

Module: FARMACOLOGIA DI BASE
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Programme


• General pharmacology
- Drug discovery (Bertazzoni Minelli E., 1 CFU)
- Pharmacokinetics
- Basic chemotherapy
- Pharmacokinetic/pharmacodynamic ratio
- Drug –delivery systems
- Nanotechnology (liposomes, nanoparticles, etc.)
- Target-specific drug therapy (enzymes, receptors, transcription factors, RNA, ecc.)
- Personalized therapy


Module: TOSSICOLOGIA MOLECOLARE E VALUTAZIONE DEL DANNO DA FARMACI
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Module: FARMACOLOGIA DI SISTEMI: RECETTORI E TRASDUZIONE DEL SEGNALE
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• Receptor pharmacology and signaling (Bertazzoni Minelli E., 1 CFU)
- Fundamentals of pharmacodynamics
- Receptors
- Mechanisms of signal transduction
- Signal transduction antibodies
- Structure- activity relationship and new drugs discovery
- Molecular interactions (CYP and pharmacophores, molecular modeling, etc.)


Module: RILEVAMENTO REAZIONI AVVERSE DA FARMACI
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Assessment methods and criteria

Module: FARMACOLOGIA DI BASE
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See the italian version


Module: TOSSICOLOGIA MOLECOLARE E VALUTAZIONE DEL DANNO DA FARMACI
-------



Module: FARMACOLOGIA DI SISTEMI: RECETTORI E TRASDUZIONE DEL SEGNALE
-------
See the italian version


Module: RILEVAMENTO REAZIONI AVVERSE DA FARMACI
-------