Metabolomica e drug discovery (2009/2010)

Course partially running

Course code
4S02448
Name of lecturer
Michael Assfalg
Coordinator
Michael Assfalg
Number of ECTS credits allocated
2
Academic sector
- - -
Language of instruction
Italian
Period
2nd Semester dal Mar 1, 2010 al Jun 15, 2010.

Lesson timetable

2nd Semester
Day Time Type Place Note
Friday 9:30 AM - 11:30 AM lesson Lecture Hall L  

Learning outcomes

The course provides the keys to understand the interactions of endogenous and exogenous small organic molecules with organisms, and corresponding applications.

Syllabus

Metabolite as ultimate indicators of gene expression and physiological processes. The metabolome. Approach in metabolomics. Anlytical techniques, including mass spectrometry and NMR spectroscopy. Multivariate statistics. Applications of metabolomics in biomarkers identification, diagnosis, toxicology. Role of metabolomics in drug discovery: efficacy, safety, and drug optimization. Drug discovery: development of molecules with pharmaceutical applications. Design of compound libraries. Fragment-based screening against biological targets. Specroscopic methods in drug screening. Rational design. Drug optimization.

Assessment methods and criteria

The final test is oral.

Statistics about transparency requirements (Attuazione Art. 2 del D.M. 31/10/2007, n. 544)

Statistics
Outcomes Exams Outcomes Percentages Average Standard Deviation
Positive 100.0% 30 0
Rejected --
Absent --
Ritirati --
Canceled --
Distribuzione degli esiti positivi
18 19 20 21 22 23 24 25 26 27 28 29 30 30 e Lode
0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 100.0%

Data from AA 2009/2010 based on 2 students. I valori in percentuale sono arrotondati al numero intero più vicino.

Studying