Genetics & Heredity

Linda Avesani
Temporary Assistant Professor
Diana Bellin
Associate Professor
Giovanni Dal Corso
Technical-administrative staff
Silvia Dal Santo
Temporary Assistant Professor
Massimo Delledonne
Full Professor
Antonella Furini
Full Professor
Mario Pezzotti
Full Professor
Sara Zenoni
Assistant Professor
Skills
Topic People Description
Consulenza genetica Alberto Turco
Consulenza genetica in malattie a trasmissione mendeliana semplice e multi fattoriale.Consulenza genetica oncologica nelle famiglie a rischi per tumore mammario e ovarico ereditari
Genetica Agraria Linda Avesani
Silvia Dal Santo
Mario Pezzotti
Sara Zenoni
Competenza
Genetics of complex diseases Giovanni Malerba
Elisabetta Trabetti
Genetic susceptibility to complex diseases, by candidate gene, genome-wide and differential gene expression analyses, also by means of NGS techniques
Genetics of Cystic Fibrosis and of Respiratory Diseases Cristina Bombieri
Carlo Castellani
Pierfranco Pignatti
Investigation on genetic factors involved in development, progression and/or severity of Cystic Fibrosis and related disorders, Asthma, Baker Occupational Asthma, Bronchiectasis, COPD, Rhinitis.
Genetica medica molecolare Maria Macarena Gomez
Associazione di varianti geniche alla predisposizione a malattie complesse; espressione genica e di microRNAs come biomarcatori di malattia, studi funzionali di regioni regolatrici della espressione genica.
Genetica molecolare Antonella Sangalli
Studi di linkage e associazione in malattie genetiche mendeliane semplici (principalmente connettivopatie) e complesse (osteoporosi). Identificazione di mutazioni in malattie genetiche semplici. Studi di predisposizione genetica al melanoma della pelle. Analisi di espressione genica.
Genetica Molecolare e Colture Cellulari Vegetali Giovanni Dal Corso
Antonella Furini
Caratterizzazione molecolare dell'interazione pianta-metalli per sviluppare approcci biotecnologici di fitorimendio e biofortificazione.
Genetica molecolare umana Monica Mottes
Basi genetiche di disordini ereditari del tessuto connettivo, in particolare Osteogenesis Imperfecta
Genetica Vegetale e Colture Cellulari Vegetali Giovanni Dal Corso
Antonella Furini
Caratterizzazione molecolare dell'interazione Pianta-metalli per sviluppare approcci biotecnologici di fitorimedio e biofortificazione.
Laboratorio di Biotecnologie genetiche Diana Bellin
Massimo Delledonne
My laboratory specialises in the characterization of NO functions at cellular and molecular levels in plants. In collaboration with Chris Lamb we made pioneering work towards the discovery of NO function during the plant hypersensitive disease resistance response. We found that during the hypersensitive response plant cells accumulate NO, which co-operates with reactive oxygen species in the induction of hypersensitive cell death, and functions independently of such intermediates in the induction of defence related genes (Delledonne et al., 1998). We then demonstrated that the rates of production and dismutation of O2- generated during the oxidative burst play a crucial role in the modulation and integration of NO/H2O2 signalling in the hypersensitive response (Delledonne et al., 2001). Due to the many possible mechanisms of NO action, a clear picture of its involvement in plant resistance to pathogens is far from being achieved. Our goal is to characterize and modulate the signal transduction pathways leading to the hypersensitive disease resistance response. We are going in deep in the analysis of genes involved in the hypersensitive cell death and in the establishment of disease resistance whose expression is under control of NO. We are also focusing on the mechanisms regulating NO level in plant, and on the identification and characterization of signalling mechanisms that operate downstream of NO accumulation. In particular, we are analysing the occurrence of NO-dependent posttranslational modification of proteins (S-nitrosylation) and studying the changes in the pattern of nitrosylated proteins during the plant hypersensitive disease resistance response. Identification of the proteins that are susceptible to this modification will help to understand the functional consequences and the relevance of S-nitrosylation in physiological and pathophysiological conditions. The group is now moving on NO signaling functions in grape, although Arabidopsis remains the model plant on which we will continue to work with
Laboratorio di Genomica Funzionale Massimo Delledonne
Mario Pezzotti
Development and validation of novel approaches for: Whole genome assembly, Whole exome sequencing etc Phased genomes and transcriptomes. CNV analysis via 10X genomics and optical maps Transcriptome analysis

Activities

Research facilities