Publications

Authors:

F., Benfatti; G., Cardillo; S., Fabbroni; L., Gentilucci; R., Perciaccante; Piccinelli, Fabio; A., Tolomelli

Title:

Zinc metal-promoted nucleophilic addition of azetidin-2-ones to aldehydes and nitriles

Year:

2005

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Synthesis

ISSN of journal:

0039-7881

N° Volume:

1

Page numbers:

61-70

Keyword:

zinc; aldehydes; condensation

Short description of contents:

The reactivity of in situ generated organozinc reagents of 3-alkenyl-3-bromoazetidin-2-ones with aromatic and aliphatic aldehydes to give the corresponding alcohol derivatives has been studied. The effect of solvent and Lewis acids has been explored in order to improve the reaction yields. The application of this methodology to nitriles and acyl chlorides allowed the preparation of the corresponding keto derivatives. The products of these reactions could be of interest on account of their structural similarity with the already known cholesterol adsorption inhibitors

Product ID:

81630

Handle IRIS:

11562/736565

Deposited On:

June 6, 2014

Last Modified:

November 26, 2022

Bibliographic citation:

F., Benfatti; G., Cardillo; S., Fabbroni; L., Gentilucci; R., Perciaccante; Piccinelli, Fabio; A., Tolomelli, Zinc metal-promoted nucleophilic addition of azetidin-2-ones to aldehydes and nitriles «Synthesis» , vol. 1 , 2005 , pp. 61-70

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo