Publications

Authors:

Milella, Michele; Orsi, Giulia; di Marco, Mariacristina; Salvatore, Lisa; Procaccio, Letizia; Noventa, Silvia; Bozzarelli, Silvia; Garajova, Ingrid; Vasile, Enrico; Giordano, Guido; Macchini, Marina; Cavaliere, Alessandro; Gaule, Marina; Bergamo, Francesca; Chiaravalli, Marta; Palloni, Andrea; Carloni, Riccardo; Bittoni, Alessandro; Niger, Monica; Rapposelli, Ilario Giovanni; Rodriquenz, Maria Grazia; Scartozzi, Mario; Mosconi, Stefania; Giommoni, Elisa; Bernardini, Ilaria; Paratore, Chiara; Spallanzani, Andrea; Bencardino, Katia; Forti, Laura; Tamburini, Emiliano; Lonardi, Sara; Scarpa, Aldo; Cascinu, Stefano; Tortora, Giampaolo; Sperduti, Isabella; Reni, Michele

Title:

Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

CANCER MEDICINE

ISSN of journal:

2045-7634

N° Volume:

14

Number or Folder:

3

Page numbers:

1-10

Keyword:

germline BRCA1/2 pathogenic variants; metastatic; olaparib; pancreatic cancer; poly(ADP‐ribose) polymerase inhibitors; real‐world experience; survival analysis

Short description of contents:

Introduction: Pancreatic cancer arising in the context of BRCA predisposition may benefit from poly(ADP-ribose) polymerase inhibitors. We analyzed real-world data on the impact of olaparib on survival in metastatic pancreatic cancer patients harboring germline BRCA mutations in Italy, where olaparib is not reimbursed for this indication. Methods: Clinico/pathological data of pancreatic cancer patients with documented BRCA1-2 germline pathogenic variants who had received first-line chemotherapy for metastatic disease were collected from 23 Italian oncology departments and the impact of olaparib exposure on overall survival (OS) was analyzed. Results: Of 114, 53 BRCA-mutant pancreatic cancer patients had received olaparib for metastatic disease. OS was significantly longer in patients who were exposed to olaparib (hazard ratio [HR] 0.568, 95% confidence interval [CI] 0.351-0.918, log-rank p = 0.02) in any setting/line of treatment; similar results were obtained for patients who received olaparib as maintenance treatment (in any line of treatment), patients who had stage IV disease at diagnosis, and patients who did not experience progressive disease as their best response to first-line chemotherapy. Exposure to olaparib in the first-line maintenance setting after platinum-based chemotherapy, however, did not significantly impact survival. At multivariate analysis, CA19.9 levels at diagnosis and response to first-line chemotherapy were independently prognostic; however, when response to chemotherapy was excluded, any exposure to olaparib was a significant independent predictor of longer OS, together with CA19.9 levels. Conclusion: The real-world data presented here support the use of olaparib for metastatic disease in germline BRCA-mutant pancreatic cancer patients, as it may significantly prolong survival.

Product ID:

144201

Handle IRIS:

11562/1153650

Last Modified:

February 20, 2025

Bibliographic citation:

Milella, Michele; Orsi, Giulia; di Marco, Mariacristina; Salvatore, Lisa; Procaccio, Letizia; Noventa, Silvia; Bozzarelli, Silvia; Garajova, Ingrid; Vasile, Enrico; Giordano, Guido; Macchini, Marina; Cavaliere, Alessandro; Gaule, Marina; Bergamo, Francesca; Chiaravalli, Marta; Palloni, Andrea; Carloni, Riccardo; Bittoni, Alessandro; Niger, Monica; Rapposelli, Ilario Giovanni; Rodriquenz, Maria Grazia; Scartozzi, Mario; Mosconi, Stefania; Giommoni, Elisa; Bernardini, Ilaria; Paratore, Chiara; Spallanzani, Andrea; Bencardino, Katia; Forti, Laura; Tamburini, Emiliano; Lonardi, Sara; Scarpa, Aldo; Cascinu, Stefano; Tortora, Giampaolo; Sperduti, Isabella; Reni, Michele, Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants «CANCER MEDICINE» , vol. 14 , n. 3 , 2025 , pp. 1-10

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