Publications

Authors:

Fierri, Ilaria; Chignola, Roberto; Stranieri, Chiara; Di Leo, Edoardo Giuseppe; Bellumori, Maria; Roncoletta, Sara; Romeo, Alessandro; Benetti, Federico; Fratta Pasini, Anna Maria; Zoccatelli, Gianni

Title:

Formulation, Characterization, and Antioxidant Properties of Chitosan Nanoparticles Containing Phenolic Compounds from Olive Pomace

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

ANTIOXIDANTS

ISSN of journal:

2076-3921

N° Volume:

13

Number or Folder:

12

Page numbers:

1-20

Keyword:

antioxidants; hydroxytyrosol; ionotropic gelation; lyophilization; nanoencapsulation; nanoparticles; oxidative stress

Short description of contents:

Olive phenolic compounds like hydroxytyrosol (OH-Tyr), tyrosol (Tyr), and their precursors have different health-promoting properties, mainly based on their strong antioxidant capacity. However, their presence in extra-virgin olive oil (EVOO) is scarce since they are primarily contained in the by-products of oil production, such as olive pomace (OP). The aim of this work was to extract and encapsulate OP phenolic compounds into chitosan-tripolyphosphate nanoparticles (NPs) using an ionotropic gelation lyophilization approach to increase their resistance to environmental and chemical stress. NPs resulted in a monodisperse (PDI: 0.21) population of cationic NPs (zeta-potential: 33 mV, size: 229 nm) with an encapsulation efficiency (EE%), expressed as total phenolic content (TPC) and total OH-Tyr + Tyr content, of 64-65%. Mannitol and maltodextrin DE 19 (MD-19) were evaluated as lyoprotectants to counteract irreversible NP aggregation during lyophilization. The NP powder freeze dried using 0.7% of MD-19 showed the best performance, returning a monodispersed population of particles after rehydration. The antioxidant capacity of the obtained NPs was confirmed both in cell-free assays and in a THP-1 cell model of oxidative stress. This method represents a promising way to deliver health-promoting olive phenols for nutraceutical purposes and, hence, to valorize otherwise wasted by-products.

Product ID:

143838

Handle IRIS:

11562/1150028

Last Modified:

January 18, 2025

Bibliographic citation:

Fierri, Ilaria; Chignola, Roberto; Stranieri, Chiara; Di Leo, Edoardo Giuseppe; Bellumori, Maria; Roncoletta, Sara; Romeo, Alessandro; Benetti, Federico; Fratta Pasini, Anna Maria; Zoccatelli, Gianni, Formulation, Characterization, and Antioxidant Properties of Chitosan Nanoparticles Containing Phenolic Compounds from Olive Pomace «ANTIOXIDANTS» , vol. 13 , n. 12 , 2024 , pp. 1-20

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