Publications

Authors:

Caldrer, Sara; Accordini, Silvia; Mazzi, Cristina; Tiberti, Natalia; Deiana, Michela; Matucci, Andrea; Rizzi, Eleonora; Tais, Stefano; Filippo, Fabio; Verzè, Matteo; Cattaneo, Paolo; Chiecchi, Gian Paolo; Castilletti, Concetta; Delledonne, Massimo; Gobbi, Federico; Piubelli, Chiara

Title:

Changes in the Adaptive Cellular Repertoire after Infection with Different SARS-CoV-2 VOCs in a Cohort of Vaccinated Healthcare Workers

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

VACCINES

ISSN of journal:

2076-393X

N° Volume:

12

Number or Folder:

3

Page numbers:

1-22

Keyword:

HCWs; SARS-CoV-2 VOCs; cell-mediated immunity; humoral immunity; vaccine

Short description of contents:

Background: Currently approved vaccines are highly effective in protecting against hospitalization and severe COVID-19 infections. How pre-existing immunity responds to new variants with mutated antigens is crucial information for elucidating the functional interplay between antibodies and B and T cell responses during infection with new SARS-CoV-2 variants. Methods: In this study, we monitored the dynamics and persistence of the immune response versus different SARS-CoV-2 variants of concern that emerged during the pandemic period (2021-2022) in a cohort of vaccinated healthcare workers, who experienced breakthrough infection in the Pre-Delta, Delta, and Omicron waves. We evaluated both the humoral and cell-mediated responses after infection. We also evaluated the anti-SARS-CoV-2 antibodies levels produced by infection in comparison with those produced after vaccination. Results: Our results highlighted that the immune response against the Delta VOC mainly involved an adaptive humoral and switched memory B cells component, even 3 months after the last vaccine dose, conversely showing a high percentage of depleted adaptive T cells. Omicron infections triggered a consistent production of non-vaccine-associated anti-N antibodies, probably to balance the spike epitope immune escape mechanisms. Conclusion: Our results suggest a direct dependence between the VOC and different humoral and B and T cell balances in the post-infection period, despite the administration of a different number of vaccine doses and the elapsed time since the last vaccination.

Product ID:

143463

Handle IRIS:

11562/1147828

Last Modified:

December 21, 2024

Bibliographic citation:

Caldrer, Sara; Accordini, Silvia; Mazzi, Cristina; Tiberti, Natalia; Deiana, Michela; Matucci, Andrea; Rizzi, Eleonora; Tais, Stefano; Filippo, Fabio; Verzè, Matteo; Cattaneo, Paolo; Chiecchi, Gian Paolo; Castilletti, Concetta; Delledonne, Massimo; Gobbi, Federico; Piubelli, Chiara, Changes in the Adaptive Cellular Repertoire after Infection with Different SARS-CoV-2 VOCs in a Cohort of Vaccinated Healthcare Workers «VACCINES» , vol. 12 , n. 3 , 2024 , pp. 1-22

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