Publications

Authors:

Pietrolucci, F.; Negri, S.; Ramos, C.; Commisso, M.; Sebastiano, Andreatta; Avesani, L.; Guzzo, F.

Title:

Bioprospection of the artemisia genus: phytochemical profile and antioxidant activity of five artemisia spp. from the lessini mountains

Year:

2024

Type of item:

Abstract in Atti di convegno

Tipologia ANVUR:

Abstract in Atti di convegno

Language:

Inglese

Congresso:

The 3rd International Electronic Conference on Plant Sciences

Place:

Online meeting

Period:

15-17 january 2024

Page numbers:

101-101

Keyword:

bioprospection; Artemisia; Artemisinin; plant secondary metabolism; LC-MS

Short description of contents:

The Artemisia genus, belonging to the Asteraceae family, is known for its wide distribution throughout temperate regions of the northern hemisphere and extensive use in traditional medicine. Plants from Artemisia genus contain a huge and various number of secondary metabolites, which contribute to a broad spectrum of bioactivities, i.e. anti-inflammatory, antimicrobial, and antiparasitic properties. One of the most significant uses of Artemisia species is in the treatment of malaria, where the compound artemisinin, isolated from A. annua leaves in 1972, has emerged as the most potent antimalarial drug. Nowadays, the discovery of new plant-derived products to be used as food supplements or drugs has been pushed by the exploitation of bioprospection approaches, even including the modern -omics techniques and targeted bioactivity assays. In this work, we selected and sampled five Artemisia species (A. absinthium L., A. alba Turra, A. annua L., A. verlotiorum Lamotte and A. vulgaris L.), with ascribed medicinal properties, growing wild in the natural areas of the Verona province (Italy). The phytochemical profile of the five species has been characterized trough the application of an UPLC-HRMS based on untargeted metabolomics approach and, in order to identify potential bioactive metabolites, we correlated their composition to the in vitro antioxidant activity data (FRAP and DPPH). In parallel, the occurrence of the lead drug compound artemisinin was investigated in the five Artemisia species. Here, we report for the first time the detection of sesquiterpenoids from the artemisinin biosynthesis pathway in the species A. alba. In addition, Artemisia spp. were used to generate cell cultures lines. The corresponding phytochemical profiles were characterized by UPLC-HRMS and compared with those of the original plants. Artemisia spp. cell cultures showed a simplified but still interesting specialized metabolome, probably resulting from cellular dedifferentiation processes

Product ID:

142334

Handle IRIS:

11562/1144633

Last Modified:

November 6, 2024

Bibliographic citation:

Pietrolucci, F.; Negri, S.; Ramos, C.; Commisso, M.; Sebastiano, Andreatta; Avesani, L.; Guzzo, F., Bioprospection of the artemisia genus: phytochemical profile and antioxidant activity of five artemisia spp. from the lessini mountains  in Book of abstracts , Proceedings of "The 3rd International Electronic Conference on Plant Sciences" , Online meeting , 15-17 january 2024 , 2024 , pp. 101-101

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo