Publications

Authors:

Negri, Stefano; Commisso, Mauro; Bisson, Leonardo; Zorzi, Gianluca; Pietrolucci, Fabio; Dusi, Valentina; Ramos, Carolina; Pinzauti, Fabio; Nigris, Sebastiano; Baldan, Barbara; Andreatta, Sebastiano; Zanini, Daniele; Fiorentin, Roberto; Carmela Caria, Maria; Maccioni, Alfredo; Farris, Emmanuele; Bagella, Simonetta; Sgadari, Francesco; Schicchi, Rosario; Geraci, Anna; Carratello, Alfredo; Martino, Emanuela; Ardenghi, Nicola; Bracco, Francesco; Cavalloro, Valeria; Fossati, Alice; Avesani, Linda; Guzzo, Flavia

Title:

Phylogenetic-guided bioprospection of the Italian flora: from the exploitation of bioactive phytochemicals to the study of chemo-evolutionary dynamics

Year:

2024

Type of item:

Contributo in atti di convegno

Tipologia ANVUR:

Contributo in Atti di convegno

Language:

Inglese

Congresso:

The 3rd International Electronic Conference on Plant Sciences

Place:

Online

Period:

15-17 January 2024

Page numbers:

109-109

Keyword:

bioprospection, Italian flora, drug discovery, specialized metabolism,

Short description of contents:

During their history, plants have evolved various physiological adaptations and a vast arsenal of biomolecules to thrive in diverse environments and coexist with other living organisms. The extensive diversity in terms of structures, functions, and bioactivities found within the specialized metabolisms of plants represents a powerful asset for bioprospection-based drug discovery approaches. At the same time, it poses a significant challenge in understanding the chemo-evolutionary dynamics of plant biodiversity, intended as the intricate relationships between the distribution and synthesis of plant metabolites and the evolutive diversification of the various taxa of land plants. In the frame of the National Biodiversity Future Center, dedicated to the monitoring, conservation, restoration and valorization of biodiversity, we set up a wide bioprospection plan including about 700 plant species representing all the vascular and non-vascular Italian flora. To cover the extensive phytochemical diversity expressed within it, species from all the Italian botanical families were selected on a phylogenetic basis, maintaining the original proportions among the various families (e.g., for the Angiosperms, in order: Asteraceae, Poaceae, Fabaceae, Rosaceae, etc.). Following their characterization through UPLC-HRMS, the species with the most interesting phytochemical profiles entered a downstream bioactivity screening program focused on non-communicable diseases and crop protection. This screening aims to identify specific phytochemicals or phytocomplexes that could be exploited to produce drugs, nutraceuticals, cosmetics and products for more sustainable agricultural practices. Moreover, the comparison of all the plant species through untargeted metabolomics will also be performed to chart the specialized metabolisms through all the families of Italian flora in order to gain greater knowledge of the relationships of their occurrence and biosynthesis with the evolution of land plants.

Product ID:

140739

Handle IRIS:

11562/1133087

Last Modified:

August 9, 2024

Bibliographic citation:

Negri, Stefano; Commisso, Mauro; Bisson, Leonardo; Zorzi, Gianluca; Pietrolucci, Fabio; Dusi, Valentina; Ramos, Carolina; Pinzauti, Fabio; Nigris, Sebastiano; Baldan, Barbara; Andreatta, Sebastiano; Zanini, Daniele; Fiorentin, Roberto; Carmela Caria, Maria; Maccioni, Alfredo; Farris, Emmanuele; Bagella, Simonetta; Sgadari, Francesco; Schicchi, Rosario; Geraci, Anna; Carratello, Alfredo; Martino, Emanuela; Ardenghi, Nicola; Bracco, Francesco; Cavalloro, Valeria; Fossati, Alice; Avesani, Linda; Guzzo, Flavia, Phylogenetic-guided bioprospection of the Italian flora: from the exploitation of bioactive phytochemicals to the study of chemo-evolutionary dynamics  in Book of abstracts , Proceedings of "The 3rd International Electronic Conference on Plant Sciences" , Online , 15-17 January 2024 , 2024 , pp. 109-109

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