Publications

Authors:

Tira, Roberto; Viola, Giovanna; Barracchia, CARLO GIORGIO; Parolini, Francesca; Munari, Francesca; Capaldi, Stefano; Assfalg, Michael; D'Onofrio, Mariapina

Title:

Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer′s Associated Tau Protein

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Journal of Agricultural and Food Chemistry

ISSN of journal:

0021-8561

N° Volume:

71

Number or Folder:

30

Page numbers:

11429-11441

Keyword:

Alzheimer′s disease; NMR; bioactive molecules; coffee; liquid−liquid phase separation; protein aggregation; tau protein

Short description of contents:

: Espresso coffee is among the most consumed beverages in the world. Recent studies report a protective activity of the coffee beverage against neurodegenerative disorders such as Alzheimer's disease. Alzheimer's disease belongs to a group of disorders, called tauopathies, which are characterized by the intraneuronal accumulation of the microtubule-associated protein tau in fibrillar aggregates. In this work, we characterized by NMR the molecular composition of the espresso coffee extract and identified its main components. We then demonstrated with in vitro and in cell experiments that the whole coffee extract, caffeine, and genistein have biological properties in preventing aggregation, condensation, and seeding activity of the repeat region of tau. We also identified a set of coffee compounds capable of binding to preformed tau fibrils. These results add insights into the neuroprotective potential of espresso coffee and suggest candidate molecular scaffolds for designing therapies targeting monomeric or fibrillized forms of tau.

Product ID:

134857

Handle IRIS:

11562/1101146

Last Modified:

October 8, 2023

Bibliographic citation:

Tira, Roberto; Viola, Giovanna; Barracchia, CARLO GIORGIO; Parolini, Francesca; Munari, Francesca; Capaldi, Stefano; Assfalg, Michael; D'Onofrio, Mariapina, Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer′s Associated Tau Protein «Journal of Agricultural and Food Chemistry» , vol. 71 , n. 30 , 2023 , pp. 11429-11441

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo