Publications

Authors:

Facchin, Sonia; Vitulo, Nicola; Calgaro, Matteo; Buda, Andrea; Romualdi, Chiara; Pohl, Daniel; Perini, Barbara; Lorenzon, Greta; Marinelli, Carla; D'Incà, Renata; Sturniolo, Giacomo Carlo; Savarino, Edoardo Vincenzo

Title:

Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

NEUROGASTROENTEROLOGY AND MOTILITY

ISSN of journal:

1350-1925

Page numbers:

1-10

Keyword:

16S metabarcoding; gut inflammation; inflammatory bowel disease; prebiotics; short-chain fatty acid

Short description of contents:

Background Butyrate has shown anti-inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic-delivery formulation of butyrate on the fecal microbiota of patients with inflammatory bowel diseases (IBDs).Methods In this double-blind, placebo-controlled, pilot study, 49 IBD patients (n = 19 Crohn's disease, CD and n = 30 ulcerative colitis, UC) were randomized to oral administration of microencapsulated-sodium-butyrate (BLM) or placebo for 2 months, in addition to conventional therapy. Eighteen healthy volunteers (HVs) were recruited to provide a healthy microbiota model of the local people. Fecal microbiota from stool samples was assessed by 16S sequencing. Clinical disease activity and quality of life (QoL) were evaluated before and after treatment.Key Results At baseline, HVs showed a different microbiota composition compared with IBD patients. Sodium-butyrate altered the gut microbiota of IBD patients by increasing bacteria able to produce SCFA in UC patients (Lachnospiraceae spp.) and the butyrogenic colonic bacteria in CD patients (Butyricicoccus). In UC patients, QoL was positively affected by treatment.Conclusions and Inferences Sodium-butyrate supplementation increases the growth of bacteria able to produce SCFA with potentially anti-inflammatory action. The clinical impact of this finding requires further investigation.

Product ID:

115092

Handle IRIS:

11562/1020060

Last Modified:

December 2, 2022

Bibliographic citation:

Facchin, Sonia; Vitulo, Nicola; Calgaro, Matteo; Buda, Andrea; Romualdi, Chiara; Pohl, Daniel; Perini, Barbara; Lorenzon, Greta; Marinelli, Carla; D'Incà, Renata; Sturniolo, Giacomo Carlo; Savarino, Edoardo Vincenzo, Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease «NEUROGASTROENTEROLOGY AND MOTILITY» , 2020 , pp. 1-10

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