Publications

Authors:

Bikdeli, Behnood; Madhavan, Mahesh V; Gupta, Aakriti; Jimenez, David; Burton, John R; Der Nigoghossian, Caroline; Chuich, Taylor; Nouri, Shayan Nabavi; Dreyfus, Isaac; Driggin, Elissa; Sethi, Sanjum; Sehgal, Kartik; Chatterjee, Saurav; Ageno, Walter; Madjid, Mohammad; Guo, Yutao; Tang, Liang V; Hu, Yu; Bertoletti, Laurent; Giri, Jay; Cushman, Mary; Quéré, Isabelle; Dimakakos, Evangelos P; Gibson, C Michael; Lippi, Giuseppe; Favaloro, Emmanuel J; Fareed, Jawed; Tafur, Alfonso J; Francese, Dominic P; Batra, Jaya; Falanga, Anna; Clerkin, Kevin J; Uriel, Nir; Kirtane, Ajay; Mclintock, Claire; Hunt, Beverley J; Spyropoulos, Alex C; Barnes, Geoffrey D; Eikelboom, John W; Weinberg, Ido; Schulman, Sam; Carrier, Marc; Piazza, Gregory; Beckman, Joshua A; Leon, Martin B; Stone, Gregg W; Rosenkranz, Stephan; Goldhaber, Samuel Z; Parikh, Sahil A; Monreal, Manuel; Krumholz, Harlan M; Konstantinides, Stavros V; Weitz, Jeffrey I; Lip, Gregory Y H

Title:

Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Thrombosis and Haemostasis

ISSN of journal:

0340-6245

N° Volume:

120

Number or Folder:

7

Page numbers:

1004-1024

Keyword:

thrombosis, COVID-19, coronavirus

Short description of contents:

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct antithrombotic effects, other mechanisms of action, including anti-inflammatory or antiviral effects, have been postulated. Based on survey results from this group of authors, we suggest research priorities for specific agents and subgroups of patients with COVID-19. Further, we review other agents, including immunomodulators, that may have antithrombotic properties. It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.

Web page:

https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0040-1713152

Product ID:

114722

Handle IRIS:

11562/1018746

Last Modified:

November 25, 2022

Bibliographic citation:

Bikdeli, Behnood; Madhavan, Mahesh V; Gupta, Aakriti; Jimenez, David; Burton, John R; Der Nigoghossian, Caroline; Chuich, Taylor; Nouri, Shayan Nabavi; Dreyfus, Isaac; Driggin, Elissa; Sethi, Sanjum; Sehgal, Kartik; Chatterjee, Saurav; Ageno, Walter; Madjid, Mohammad; Guo, Yutao; Tang, Liang V; Hu, Yu; Bertoletti, Laurent; Giri, Jay; Cushman, Mary; Quéré, Isabelle; Dimakakos, Evangelos P; Gibson, C Michael; Lippi, Giuseppe; Favaloro, Emmanuel J; Fareed, Jawed; Tafur, Alfonso J; Francese, Dominic P; Batra, Jaya; Falanga, Anna; Clerkin, Kevin J; Uriel, Nir; Kirtane, Ajay; Mclintock, Claire; Hunt, Beverley J; Spyropoulos, Alex C; Barnes, Geoffrey D; Eikelboom, John W; Weinberg, Ido; Schulman, Sam; Carrier, Marc; Piazza, Gregory; Beckman, Joshua A; Leon, Martin B; Stone, Gregg W; Rosenkranz, Stephan; Goldhaber, Samuel Z; Parikh, Sahil A; Monreal, Manuel; Krumholz, Harlan M; Konstantinides, Stavros V; Weitz, Jeffrey I; Lip, Gregory Y H, Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research «Thrombosis and Haemostasis» , vol. 120 , n. 7 , 2020 , pp. 1004-1024

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo