Publications

Authors:

Magro, Daniéla Oliveira; Santos, Andrey; Guadagnini, Dioze; de Godoy, Flavia Moreira; Silva, Sylvia Helena Monteiro; Lemos, Wilson José Fernandes; Vitulo, Nicola; Torriani, Sandra; Pinheiro, Lilian Vital; Martinez, Carlos Augusto Real; Saad, Mario José Abdalla; Coy, Claudio Saddy Rodrigues

Title:

Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

9

Number or Folder:

1

Page numbers:

1-10

Keyword:

Crohn’s disease, microbiome

Short description of contents:

Previous studies have demonstrated that patients with Crohn's disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses. The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analytical cross-sectional single center study, which recruited 18 CD patients and 18 healthy controls (CG) residing in the same home, meaning that all of the participants experienced the same environmental factors, with similar hygiene status, diet, pollution and other common lifestyle characteristics that may influence the composition of the gut microbiota. When compared to healthy controls, the CD patients exhibited lower microbial et-diversity (p = 0.047), a greater abundance of the Proteobacteria phylum (p = 0.037) and a reduction in the Deltaproteobacteria class (p = 0.0006). There was also a reduction in the Akkermansia (p = 0.002) and Oscillospira (p = 0.024) genera and in the proportion of the yeast Saccharomyces cerevisiae (p = 0.01). Additionally, CD patients in remission presented increased neutral (p = 0.001) and acid mucin (p = 0.002) concentrations. The reductions in the proportions of Oscollospira and Akkermansia genera, sulfate-reducing bacteria and Saccharomyces cerevisiae, observed in the CD group, may account for the increased mucins production observed in these patients.

Product ID:

111671

Handle IRIS:

11562/1009021

Last Modified:

November 28, 2022

Bibliographic citation:

Magro, Daniéla Oliveira; Santos, Andrey; Guadagnini, Dioze; de Godoy, Flavia Moreira; Silva, Sylvia Helena Monteiro; Lemos, Wilson José Fernandes; Vitulo, Nicola; Torriani, Sandra; Pinheiro, Lilian Vital; Martinez, Carlos Augusto Real; Saad, Mario José Abdalla; Coy, Claudio Saddy Rodrigues, Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production «SCIENTIFIC REPORTS» , vol. 9 , n. 1 , 2019 , pp. 1-10

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