The aim of this project is to investigate the validity of the NMR metabolomic approach to the study of pancreatic cancer.
Pancreatic cancer incidence and mortality virtually coincide having a five-year survival of less than 5%. Surgical intervention is possible in only about 10% of cases and adjuvant therapies are virtually ineffective. It becomes therefore necessary to pursue new and unexplored research approaches to face the treatment of the pathology.
- Multiple collection of urine from patients affected by pancreatic cancer;
- registration of metabolic profiles with NMR spectroscopy;
- analysis of the interindividual variations and description of behavioural classes;
- determination of the significant spectral regions of the metabolic profiles;
- comparison with annotated repository of biofluid samples and “healthy” controls;
- description of predictive models of the pathology;
- conclusions about the diagnostic and prognostic applicability of the method.