Paola Dominici

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Foto, June 14, 2018
Position
Full Professor
Academic sector
BIOS-07/A - Biochemistry
Research sector (ERC-2024)
LS1_1 - Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates

LS1_7 - Molecular biophysics, biomechanics, bioenergetics

Research sector (ERC)
LS1_8 - Biophysics (e.g. transport mechanisms, bioenergetics, fluorescence)

LS1_1 - Molecular interactions

Office
Ca' Vignal 1,  Floor 2,  Room 2.19b
Telephone
045 802 7966; Lab: 045 802 7956-7086
E-mail
paola|dominici*univr|it <== Replace | with . and * with @ to have the right email address.

Office Hours

Monday, Hours 2:30 PM - 4:30 PM,  

Curriculum

My scientific interests are directed to the biochemistry and biophysics of proteins, with particular attention to the studies on the structure, function and evolution of pyridoxal 5'-phosphate (PLP) -dependent enzymes and metallo-proteins.

•Characterization of the stability, catalytic mechanism and specificity of pyridoxal phosphate- dependent enzymes, including DOPA decarboxylase, Glutamic acid decarboxylase, cystathionine beta synthase, ornithine aminotransferase and cystathionine gamma lyase.

•Elucidation of structure-dynamics-function relationships of non-symbiotic plant hemoglobins exploiting biochemical and biophysical methods.

•Calcium sensors (calmodulin and centrins) and the mechanisms by which these proteins regulate complex molecular calcium-dependent processes in different organisms.

•Characterization of enzymes with peptidyl-prolyl isomerase (PPIase) activity. These enzymes belong to the cyclophilin family and play crucial roles in various biological processes (e.g. host invasion and pathogen survival). They are considered pivotal virulence factors, making them attractive drug candidates for the development of new antimicrobial molecules.

Modules

Modules running in the period selected: 94.
Click on the module to see the timetable and course details.

Course Name Total credits Online Teacher credits Modules offered by this teacher
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2025/2026)   12  eLearning 2  BIOCHIMICA ANALITICA (teoria)
8  BIOCHIMICA
Bachelors' degree in Innovation and sustainability in the industrial production of food Nutrition biochemistry (2025/2026)   4  eLearning 2 
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2025/2026)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2024/2025)   12  eLearning 8  BIOCHIMICA
2  BIOCHIMICA ANALITICA (teoria)
Bachelors' degree in Innovation and sustainability in the industrial production of food Nutrition biochemistry (2024/2025)   4  eLearning 2 
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2024/2025)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2023/2024)   12  eLearning 8  BIOCHIMICA
2  BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2023/2024)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2022/2023)   12  eLearning 8  BIOCHIMICA
2  BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2022/2023)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2021/2022)   12  eLearning 8  BIOCHIMICA
2  BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2021/2022)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2020/2021)   12  eLearning 8  BIOCHIMICA
2  BIOCHIMICA ANALITICA [2° turno] (laboratorio)
2  BIOCHIMICA ANALITICA [1° turno] (laboratorio)
2  BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2020/2021)   6  eLearning 5 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2019/2020)   12  eLearning 8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
2  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2019/2020)   6  eLearning 6 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2018/2019)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
2  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2018/2019)   6    6 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2017/2018)   12    2  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2017/2018)   6    6 
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2016/2017)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2016/2017)   6    6 
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2016/2017)   6  eLearning 1  (b)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2015/2016)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Molecular and Medical Biotechnology Protein misfolding and human diseases (2015/2016)   6    6 
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2015/2016)   6    1  (b)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2014/2015)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Bioinformatics and Medical Biotechnology Protein engineering (2014/2015)   6    1  (laboratorio)
5  (teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2013/2014)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Bioinformatics and Medical Biotechnology Protein engineering (2013/2014)   6    1  (laboratorio)
5  (teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2012/2013)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Bioinformatics and Medical Biotechnology Protein engineering (2012/2013)   6    1  (Laboratorio)
5  (Teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2011/2012)   12    2  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (Teoria)
2  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (Laboratorio)
8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Master's degree in Bioinformatics and Medical Biotechnology Protein engineering (2011/2012)   6    1  (Laboratorio)
5  (Teoria)
Master's degree in Agri-Food Biotechnology Applied enzymology (2010/2011)   6    3  (Mod 2)
3  (Mod 1)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2010/2011)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2010/2011)   3    1  LABORATORIO
2  TEORIA
Master's degree in Agri-Food Biotechnology Applied enzymology (2009/2010)   6    3  (Mod 1)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2009/2010)   12    8  BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2009/2010)   3    1  LABORATORIO
2  TEORIA
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2008/2009)   9    5  Teoria A
2  Laboratorio
2  Teoria B
5  Teoria A
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2008/2009)   3    1  Laboratorio
2  Teoria
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2007/2008)   9    5  Teoria 1
2  Laboratorio [2° turno]
2  Teoria 2
2  Laboratorio [1° turno]
5  Teoria 1
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2007/2008)   3    1  Laboratorio
2  Teoria
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2006/2007)   9    2  Laboratorio [I Turno]
7  Teoria
7  Teoria
2  Laboratorio [II Turno]
Masters in Molecular and Industrial Biotechniques Enzymology (2006/2007)   4    4 
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2006/2007)   3    1  Laboratorio
2  Teoria
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2005/2006)   9    7  Teoria
2  Laboratorio
7  Teoria
Masters in Molecular and Industrial Biotechniques Production and characterisation of recombinant proteins (2005/2006)   3    1  Laboratorio
2  Teoria
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2004/2005)   9     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2003/2004)   9     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2002/2003)   9     
Bachelor in Agroindustrial Biotechnology (until 2008-2009 academic year) Biochemistry (2001/2002)   9     
Bachelor in Agroindustrial Biotechnology (old system) Biochemistry (Biological Chemistry - Plant Biochemistry) (2001/2002)   180     
Bachelor in Agroindustrial Biotechnology (old system) Biochemistry (Biological Chemistry - Plant Biochemistry) (2000/2001)   180     
Bachelor in Agroindustrial Biotechnology (old system) Enzymology (2000/2001)   60     
Bachelor in Agroindustrial Biotechnology (old system) Biochemistry (Biological Chemistry - Plant Biochemistry) (1999/2000)   180     
Bachelor in Agroindustrial Biotechnology (old system) Enzymology (1999/2000)   60     

Di seguito sono elencati gli eventi e gli insegnamenti di Terza Missione collegati al docente:

  • Eventi di Terza Missione: eventi di Public Engagement e Formazione Continua.
  • Insegnamenti di Terza Missione: insegnamenti che fanno parte di Corsi di Studio come Corsi di formazione continua, Corsi di perfezionamento e aggiornamento professionale, Corsi di perfezionamento, Master e Scuole di specializzazione.

Research groups

Biochimica
Responsabile: prof.ssa Paola Dominici – Referente sicurezza: Alessandra Astegno
Research interests
Topic Description Research area
Interazioni proteina-ligando Studio dei meccanismi molecolari della interazione di ligandi con proteine calcio-sensori ed eme- proteine Structural , functional and expression proteomics
Molecular interactions
Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates Biochimica e Biologia Molecolare
Macromolecular complexes including interactions involving Nucleic Acids, Proteins, Lipids and Carbohydrates
Molecular biophysics, biomechanics, bioenergetics Molecular biophysics, biomechanics, bioenergetics Biochimica e Biologia Molecolare
Molecular biophysics, biomechanics, bioenergetics
Proteine ricombinanti ed Ingegneria proteica Produzione di proteine ricombinanti in sistemi di espressione procariotici. Ingegnerizzazione proteica mediante mutagenesi razionale. Structural , functional and expression proteomics
Applied genetic engineering, transgenic organisms, recombinant proteins, biosensors
Studio del rapporto struttura/funzione di enzimi Meccanismi catalitici e regolatori di enzimi piridossal-fosfato-dipendent Structural , functional and expression proteomics
General biochemistry and metabolism
Projects
Title Starting date
LYLAC 3/1/21
PRIN2017 - Regulatory signals and redox systems in plant growth-defence trade off 8/29/19
Improving wine aroma complexity by directed evolution of non-Saccharomyces yeast enzymes 6/1/17
Enzyme engineering for quality assessment of olive oil 1/1/16
Engineering volatile thiol release for improved wine aroma: Directed evolution of yeast cystathionine ß-lyase 1/1/13
Nuove tecnologie per il made in Italy 8/1/10
Emoglobine vegetali esacoordinate: ruolo dei residui distali della tasca di legame dell'eme 10/1/05
Studi strutturali e funzionali sulle emoglobine di Arabidopsis 9/1/04
Emoglobine non simbiotiche da Arabidopsis: aspetti strutturali e funzionali dell'interazione con ossido nitrico (2004) 1/1/04
Post genomica di leguminose foraggere 11/5/02
EMOGLOBINE E OSSIDO NITRICO NELLE RISPOSTE DI DIFESA DELLA PIANTA (2002) 1/1/02
Meccanismi molecolari di fotoprotezione nelle piante superiori (2000) 1/1/00



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