Alessandra Astegno

Foto_Astegno,  March 3, 2018
Position
Associate Professor
Academic sector
BIO/10 - BIOCHEMISTRY
Research sector (ERC)
LS1_2 - General biochemistry and metabolism

LS1_1 - Molecular interactions

LS9_1 - Non-medical biotechnology and genetic engineering (including transgenic organisms, recombinant proteins, biosensors, bioreactors, microbiology)

Office
Ca' Vignal 1,  Floor 2,  Room 2.03
Telephone
045802 7955
E-mail
alessandra|astegno*univr|it <== Replace | with . and * with @ to have the right email address.

Office Hours

Tuesday, Hours 11:00 AM - 12:00 PM,  

Curriculum

Dr Astegno is interested in the characterization of enzymes, their interaction, regulation and inhibition as a therapeutic strategy. She is expert in the study of enzymes dependent on pyridoxal 5’-phosphate, that include most of the enzymes involved in amino acid metabolism both in mammals and bacteria. Presently, her research focuses on the study of the enzymes from both parasitic organisms (Toxoplasma gondii) and bacteria (Pseudomonas aeruginosa) involved in cysteine biosynthesis (specially those regulating the Transsulfuration pathway) and their exploitation as target for innovative drugs. She is also involved in the biochemical characterization of cyclosporin A-binding cyclophilins from the parasite T.gondii which have received increasing attention for the development of alternative therapeutic strategies against protozoa mediated diseases. Moreover, her research interests concern calcium sensors (calmodulin and centrins) and the mechanisms by which these proteins regulate complex molecular processes in different organisms.

Modules

Modules running in the period selected: 47.
Click on the module to see the timetable and course details.

Course Name Total credits Online Teacher credits Modules offered by this teacher
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2022/2023)   12    BIOCHIMICA ANALITICA [2° turno] (laboratorio)
Bachelor's degree in Bioinformatics Bio-information technology workshop (2022/2023)   12    (Mod.2 Laboratorio)
Master's degree in Molecular and Medical Biotechnology Enzymology in medical biotechnology (2022/2023)   6    (Teoria)
[3° turno] (Laboratorio)
[2° turno] (Laboratorio)
[1° turno] (Laboratorio)
Master's degree in Molecular and Medical Biotechnology Enzymology in medical biotechnology (2021/2022)   6  eLearning [1° turno] (Laboratorio)
[3° turno] (Laboratorio)
[2° turno] (Laboratorio)
(Teoria)
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2020/2021)   6  eLearning [2° turno] (Modulo A Laboratorio)
[3° turno] (Modulo A Laboratorio)
(Modulo A)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2019/2020)   12  eLearning BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (laboratorio)
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2019/2020)   6  eLearning [2° turno] (a)
[1° turno] (a)
[3° turno] (a)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2018/2019)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [laboratorio 1° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [laboratorio 2° turno] (laboratorio)
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2018/2019)   6    [turno 2] (a)
[turno 3] (a)
[turno 1] (a)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2017/2018)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (laboratorio)
Master's degree in Molecular and Medical Biotechnology Research inspired laboratory (2017/2018)   6  eLearning (a)
PhD in Biotechnology The human olfactory system (2017/2018)   10   
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2016/2017)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2015/2016)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2014/2015)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (teoria)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (laboratorio)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2013/2014)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (Teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2012/2013)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [1° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (Teoria)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2011/2012)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [3° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [4° turno] (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA [2° turno] (Laboratorio)
Bachelor's degree in Biotechnology Biochemistry and analytical biochemistry (2010/2011)   12    BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (Laboratorio)
BIOCHIMICA E BIOCHIMICA ANALITICA: BIOCHIMICA ANALITICA (Teoria)

 
 

Research groups

Biochimica
Responsabile: prof.ssa Paola Dominici – Referente sicurezza: Alessandra Astegno
Research interests
Topic Description Research area
Caratterizzazione biochimica di proteine ad attività enzimatica Meccanismi catalitici e regolatori di enzimi dipendenti dalla vitamina B6 Structural , functional and expression proteomics
General biochemistry and metabolism
Proteine ricombinanti ed Ingegneria proteica Produzione di proteine ricombinanti in sistemi di espressione procariotici. Ingegnerizzazione proteica mediante mutagenesi razionale. Structural , functional and expression proteomics
Applied genetic engineering, transgenic organisms, recombinant proteins, biosensors
Studio delle interazioni proteina-ligando Meccanismi molecolari della interazione di ligandi con proteine calcio-sensori ed emeproteine Structural , functional and expression proteomics
Molecular interactions
Projects
Title Starting date
PRIN2017 - Regulatory signals and redox systems in plant growth-defence trade off 8/29/19
Engineering a fusion enzyme for determination of bioactive amines 1/1/16
Studi strutturali e funzionali sulle calmoduline e calmodulin-like proteins di Arabidopsis 1/1/15
Enzimi PLP-dipendenti come target di molecole ad azione antimicrobica e chemioterapica 1/1/15
Identificazione e caratterizzazione di proteine e peptidi bioattivi poco abbondanti del siero di latte 10/1/09




Organisation

Department facilities