System biology - SYSTEM BIOLOGY E RETI BIOLOGICHE IN PATOLOGIA: ESEMPI E APPLICAZIONI (2010/2011)

Course not running

Course code
4S000696
Name of lecturer
Gabriela Constantin
Number of ECTS credits allocated
4
Academic sector
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Language of instruction
Italian
Location
VERONA
Period
II semestre dal Mar 1, 2011 al Jun 15, 2011.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

Learning outcomes

The class will provide the students with an overview of different aspects of Systems Biology applied to life and medical science. The class will be initially focused on general aspects of Systems Biology, including the concepts of complexity, emergent properties, abstraction, mathematical modeling and biological networks. the course will provide a number of examples regarding general principles and methods typical of systems biology, data-bases and software widely used in the field. Furthermore, in the course we will introduce as propaedeutic background, some examples of complex systems in biology, including signal transduction and metabolic networks. In the second part of the course we will proceed with the description of complex systems relevant to medicine, such as the immune systems, autoimmune diseases and cancer in the context of systems biology. Several examples will be explained and extensively illustrated. Moreover, a general view of systems biology in the context of a transition toward personalized medicine will be proposed.

Syllabus

1) Complexity: definition and its nature in biology
2) Emergent properties: cell and molecular circuits
3) The deductive and inductive methods in science
4) Systems Biology: definition and principle
5) Why systems biology: the reductionist versus holistic approach in science
6) Modeling
7) Static modeling and the graph abstraction; network theory
8) Dynamic modeling

9) Methods in Systems Biology: high throughput technologies
10) Methods in Systems Biology: bioinformatcis
11) Methods in Systems Biology: data-bases
12) Methods in Systems Biology: software for systems biology

13) Systems Biology contexts: trascriptomic, proteomic and metabolic networks

14) Application of Systems Biology: networks in diseases
15) Application of Systems Biology: the immune system
16) Application of Systems Biology: inflammation
17) Application of Systems Biology: cancer
18) Application of Systems Biology: neurodegenerative diseases
19) Application of Systems Biology; autoimmune diseases
20) Application of Systems Biology: systems farmacology e drug discovery

Assessment methods and criteria

Written exam with multiple Q&A