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Course organization
The aim of the course is to provide the students the tools needed for the analysis and interpretration of the biological data. Indeed, the course intends to give the theortical basis for the application of the principal bioinformatic tools, used in genomics and proteomics
Biological databases. FASTA format. We will analyze the way in which the principal biological databases are used for the anotation of genomes. ENSEMBL.
Methods for the prediction and the annotation of the functional elements of a genome
Computational approaches in comparative genomics.
Using DNA microarrays to Assay gene expression.
Sequence alignment. Scoring matrices PAM and BLOSUM. Algorithms. Profiles.
Protein evolution.
3D protein structure prediction: Comparative modelling, Fold recognition and ab initio methods.
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