The aim of this teaching is to analyze the biochemical process of protein synthesis and to explore the different post-traslational modification and their functions.
The course also analyzes and the structural and molecular aspects of regulatory processes and the evolutionary aspects in protein biosynthasis.
Protein Biosynthesis. The biosynthetic pathway: molecular and evolutionary aspercts. Aminoacyl-tRNA synthases. Regulation of the translational process in eukaryotes. Non-canonical translation.
Post-translational modifications: covalent modifications, glycosylation and glycoprotein biosynthesis, ADP-ribosylation, covalen binding with lipid molecules, proteolitic cleavage of inactive precursors, protein splicing.
Protein folding: structural motifs and chaperone-assisted protein folding.
The life of the proteins. Protein targeting. Protein turnover. Protein aging. Proteasome and Caspases.
Power point presentation of a research article.
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