Protein biosynthesis (2006/2007)

Course partially running

Course code
Name of lecturer
Massimo Crimi
Number of ECTS credits allocated
Academic sector
- - -
Language of instruction
1st semester dal Oct 2, 2006 al Jan 24, 2007.

Lesson timetable

Learning outcomes

The aim of this teaching is to analyze the biochemical process of protein synthesis and to explore the different post-traslational modification and their functions.
The course also analyzes and the structural and molecular aspects of regulatory processes and the evolutionary aspects in protein biosynthasis.


Protein Biosynthesis. The biosynthetic pathway: molecular and evolutionary aspercts. Aminoacyl-tRNA synthases. Regulation of the translational process in eukaryotes. Non-canonical translation.

Post-translational modifications: covalent modifications, glycosylation and glycoprotein biosynthesis, ADP-ribosylation, covalen binding with lipid molecules, proteolitic cleavage of inactive precursors, protein splicing.

Protein folding: structural motifs and chaperone-assisted protein folding.

The life of the proteins. Protein targeting. Protein turnover. Protein aging. Proteasome and Caspases.

Reference books
Author Title Publisher Year ISBN Note
Mathews, VanHolde Biochimica (Edizione 3) Ambrosiana 2004 8840812873
Terry A. Brown conoscere la biochimica (Edizione 1) Zanichelli ed., Bologna 2018
Garrett & Grisham Principi di Biochimica Piccin - Padova 2004 88-2991693

Assessment methods and criteria

Power point presentation of a research article.