Realizzazione e validazione sperimentale di un modello numerico di crescita di sferoidi tumorali

Starting date
October 30, 2005
Duration (months)
24
Departments
Biotechnology
Managers or local contacts
Chignola Roberto
URL
http://vbl.ts.infn.it

The genome does not uniquely determine cell development: both the environment and cell-cell interactions also play an important
role, inasmuch as they regulate gene expression. It is difficult and often unreliable to collect data in vivo. In vitro procedures are
much easier and yield data also on processes otherwise inaccessible in vivo; nonetheless, in vitro cultures do not reproduce the cell
environment faithfully, and data collection requires a lot of effort which is not always rewarded by satisfactory and complete results.
We are now developing a numerical engine to simulate the growth of cell clusters, and especially multicell tumor spheroids, which
includes the environment. In this project we plan to continue this work and obtain a working prototype program that includes all the
essential parts.
The simulator shall be a true in silico cell laboratory, where it will be possible to carry out virtual experiments in a controlled way.

Sponsors:

PRIN VALUTATO POSITIVAMENTE
Funds: assigned and managed by the department
Syllabus: PRIN

Project participants

Roberto Chignola
Associate Professor

Collaboratori esterni

Edoardo Milotti
Università di Trieste Dipartimento di Fisica

Activities

Research facilities