Pilot project of metabolomics by Nuclear Magnetic Resonance spectroscopy applied to the study of pancreatic cancer

Starting date
January 30, 2008
Duration (months)
24
Departments
Biotechnology
Managers or local contacts
Assfalg Michael
Keyword
Biofluids, Pancreatic cancer, Metabolomics, Nuclear magnetic resonance, Biomarker

The aim of this project is to investigate the validity of the NMR metabolomic approach to the study of pancreatic cancer.
Pancreatic cancer incidence and mortality virtually coincide having a five-year survival of less than 5%. Surgical intervention is possible in only about 10% of cases and adjuvant therapies are virtually ineffective. It becomes therefore necessary to pursue new and unexplored research approaches to face the treatment of the pathology.
  • Multiple collection of urine from patients affected by pancreatic cancer;
  • registration of metabolic profiles with NMR spectroscopy;
  • analysis of the interindividual variations and description of behavioural classes;
  • determination of the significant spectral regions of the metabolic profiles;
  • comparison with annotated repository of biofluid samples and “healthy” controls;
  • description of predictive models of the pathology;
  • conclusions about the diagnostic and prognostic applicability of the method.

Sponsors:

Ateneo
Funds: assigned and managed by the department
Syllabus: COFATENEO - Cofinanziamento Ateneo progetti di ricerca di Interesse nazionale
BRUKER DALTONICS SRL
Funds: assigned and managed by the department
Syllabus: COFATENEO - Cofinanziamento Ateneo progetti di ricerca di Interesse nazionale
Funds: assigned and managed by the department

Project participants

Michael Assfalg
Associate Professor
Stefano Barbi
Technical-administrative staff
Mariapina D'Onofrio
Assistant Professor

Activities

Research facilities