Pubblicazioni

Autori:

Giuliani, Cristina; Pirazzini, Chiara; Delledonne, Massimo; Xumerle, Luciano; Descombes, Patrick; Marquis, Julien; Mengozzi, Giacomo; Monti, Daniela; Bellizzi, Dina; Passarino, Giuseppe; Luiselli, Donata; Franceschi, Claudio; Garagnani, Paolo

Titolo:

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Mechanisms of Ageing and Development

ISSN Rivista:

0047-6374

N° Volume:

165

Numero o Fascicolo:

Pt B

Intervallo pagine:

195-201

Parole chiave:

Age-related diseases; Extreme phenotypes; Gene–environment interactions; Longevity; Populations

Breve descrizione dei contenuti:

In this review, we address the genetic continuum between aging and age-related diseases, with particular attention to the ecological perspective. We describe the connections between genes that promote longevity and genes associated with age-related diseases considering tradeoff mechanisms in which the same genetic variants could have different effects according to the tissue considered and could be involved in several biological pathways. Then we describe mechanisms of antagonistic pleiotropy, focusing on the complex interplay between genetic variants and environmental changes (internal or external). We sustain the use of centenarians as "super-controls" for the study of the major age-related diseases, starting from the concept that the maximization of the phenotypic differences in the considered cohort, achieved by selecting the most divergent phenotypes, could be useful for increasing the significant differences observed in the genetic association study. We describe the potential impact of the population genetic variability in the study of human longevity and the possible contribution of the past selective pressures in shaping the current genomic background of individuals. In conclusion, we illustrate recent findings emerged from whole-genome sequencing of long-lived individuals and future perspectives for interpreting the huge amount of genetic data that will be generated in the next future.

Id prodotto:

100942

Handle IRIS:

11562/973889

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Giuliani, Cristina; Pirazzini, Chiara; Delledonne, Massimo; Xumerle, Luciano; Descombes, Patrick; Marquis, Julien; Mengozzi, Giacomo; Monti, Daniela; Bellizzi, Dina; Passarino, Giuseppe; Luiselli, Donata; Franceschi, Claudio; Garagnani, Paolo, Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases «Mechanisms of Ageing and Development» , vol. 165 , n. Pt B , 2017 , pp. 195-201

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo