Pubblicazioni

Autori:

G. N., Lemgo; S., Sabbadini; Pandolfini, Tiziana; B., Mezzetti

Titolo:

Biosafety considerations of RNAi-mediated virus resistance in fruit-tree cultivars and in rootstock.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Transgenic Research

ISSN Rivista:

0962-8819

N° Volume:

22

Editore:

Kluwer

Intervallo pagine:

1073-1088

Parole chiave:

Biosafety; virus resistance; gene silencing; RNA interference; rootstock

Breve descrizione dei contenuti:

A major application of RNA interference(RNAi) is envisaged for the production of virusresistanttransgenic plants. For fruit trees, this remainsthe most, if not the only, viable option for the controlof plant viral disease outbreaks in cultivated orchards,due to the difficulties associated with the use oftraditional and conventional disease-control measures.The use of RNAi might provide an additional benefitfor woody crops if silenced rootstock can efficientlytransmit the silencing signal to non-transformedscions, as has already been demonstrated in herbaceousplants. This would provide a great opportunityto produce non-transgenic fruit from transgenic rootstock.In this review, we scrutinise some of theconcerns that might arise with the use of RNAi forengineering virus-resistant plants, and we speculatethat this virus resistance has fewer biosafety concerns.This is mainly because RNAi-eliciting constructs onlyexpress small RNA molecules rather than proteins,and because this technology can be applied using plantrootstock that can confer virus resistance to the scion,leaving the scion untransformed. We discuss the mainbiosafety concerns related to the release of new typesof virus-resistant plants and the risk assessmentapproaches in the application of existing regulatorysystems (in particular, those of the European Union,the USA, and Canada) for the evaluation and approvalof RNAi-mediated virus-resistant plants, either astransgenic varieties or as plant virus resistanceinduced by transgenic rootstock.

Id prodotto:

79178

Handle IRIS:

11562/652172

depositato il:

14 gennaio 2014

ultima modifica:

1 dicembre 2022

Citazione bibliografica:

G. N., Lemgo; S., Sabbadini; Pandolfini, Tiziana; B., Mezzetti, Biosafety considerations of RNAi-mediated virus resistance in fruit-tree cultivars and in rootstock. «Transgenic Research» , vol. 22 , 2013 , pp. 1073-1088

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