Pubblicazioni

Autori:

K., Kristensson; D. K., Dastur; D. K., Manghani; H., Tsiang; BENTIVOGLIO FALES, Marina

Titolo:

Rabies: Interactions between neurons and viruses: A review of the history of Negri inclusion bodies

Anno:

1996

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Neuropathology and Applied Neurobiology

ISSN Rivista:

0305-1846

N° Volume:

22

Numero o Fascicolo:

3

Intervallo pagine:

179-187

Parole chiave:

neuron; virus; rabies; Negri bodies; nervous system; viral infections

Breve descrizione dei contenuti:

The first clear-cut description of a virus-nerve cell interaction was made by Adeichi Negri in 1903 with the detection of cytoplasmic bodies (Negri bodies) in subsets of neurons in the brain from rabies-infected animals. A biographical sketch of Negri is given here; he was born in Perugia, Italy, in 1875 and died in Pavia in 1912. In 1900 Negri became assistant to Camillo Golgi, who encouraged him to study rabies-infected brains with histological techniques. The report of intraneuronal bodies described by Negri as specific for rabies stimulated an intense debate both concerning their diagnostic value and their nature. The diagnostic value was finally determined in a study by Negri's wife, Lina Negri-Luzzani, in 1913, while the viral nature of the bodies had to await the introduction of electron microscopy and immunohistochemistry. However, the true significance of the Negri bodies is still mysterious, since they only develop in subsets of infected neurons and occur mainly after infection with wild. so-cal led 'street', virus strains and not after infection with strains passaged in the laboratory, so-called 'fixed' strains.

Id prodotto:

5750

Handle IRIS:

11562/5750

ultima modifica:

16 novembre 2022

Citazione bibliografica:

K., Kristensson; D. K., Dastur; D. K., Manghani; H., Tsiang; BENTIVOGLIO FALES, Marina, Rabies: Interactions between neurons and viruses: A review of the history of Negri inclusion bodies «Neuropathology and Applied Neurobiology» , vol. 22 , n. 3 , 1996 , pp. 179-187

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo