Pubblicazioni

Autori:

Farace, Paolo; Galie', Mirco; Merigo, Flavia; Daducci, Alessandro; Calderan, Laura; Nicolato, Elena; Degrassi, A.; Pesenti, E.; Sbarbati, Andrea; Marzola, Pasquina

Titolo:

Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas.

Anno:

2009

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

British Journal of Cancer

ISSN Rivista:

0007-0920

N° Volume:

100

Numero o Fascicolo:

10

Intervallo pagine:

1575-1580

Parole chiave:

angiogenesis; DCE-MRI; SU6668; vascular heterogeneity; HT-29; cluster analysis

Breve descrizione dei contenuti:

Dynamic contrast-enhanced (albumin-Gd-DTPA) magnetic resonance imaging, performed during 2 weeks of daily administration of an inhibitor of tyrosine kinase receptors (SU6668) in an HT-29 colon carcinoma model, revealed the onset of a hyper-enhancing rim, not observed in untreated tumours. To account for tissue heterogeneity in the quantitative analysis, we segmented tumours into three subunits automatically identified by cluster analysis of the enhancement curves using a k-means algorithm. Transendothelial permeability (Kps) and fractional plasma volume (fPV) were calculated in each subunit. An avascular and necrotic region, an intermediate zone and a well-vascularised periphery were reliably identified. During untreated tumour growth, the identified sub-regions did not substantially change their enhancement pattern. Treatment with SU6668 induced major changes at tumour periphery where a significant increase of Kps and fPV was observed with respect to control tumours. Histology revealed a sub-capsular layer composed of hyper-dense viable tumour cells in the periphery of untreated tumours. The rim of viable neoplastic cells was reduced in treated tumours, and replaced by loose connective tissue characterised by numerous vessels, which explains the observed hyper-enhancement. The present data show a peripheral abnormal development of cancer-associated stroma, indicative of an adaptive response to anti-angiogenic treatment.

Pagina Web:

http://www.nature.com/bjc/journal/v100/n10/abs/6605041a.html

Id prodotto:

51901

Handle IRIS:

11562/332663

depositato il:

21 ottobre 2013

ultima modifica:

8 novembre 2022

Citazione bibliografica:

Farace, Paolo; Galie', Mirco; Merigo, Flavia; Daducci, Alessandro; Calderan, Laura; Nicolato, Elena; Degrassi, A.; Pesenti, E.; Sbarbati, Andrea; Marzola, Pasquina, Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas. «British Journal of Cancer» , vol. 100 , n. 10 , 2009 , pp. 1575-1580

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