Pubblicazioni

Autori:

Ben Khlifa, Emna; Campese, Alessia; Corsi, Andrea; Bombieri, Cristina; Romanelli, Maria Grazia; Valenti, Maria Teresa; Zipeto, Donato; Castelli, Matteo; Lievens, Patricia Marie-Jeanne; Ruggiero, Alessandra

Titolo:

Post-Translational Modifications in Respiratory Virus Infection: Recent Insights into the Development of In Vitro Models

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN Rivista:

1422-0067

N° Volume:

26

Numero o Fascicolo:

24

Intervallo pagine:

1-20

Parole chiave:

emerging respiratory viruses; organoids; post-translational modifications; virus infection; virus–host interaction

Breve descrizione dei contenuti:

Post-translational modifications (PTMs) are crucial chemical alterations occurring on proteins post-synthesis, impacting various cellular processes. During viral infections, PTMs are shown to play a multitude of roles in viral replication, host interaction, and immune evasion. Thus, these modifications can influence infectivity, with direct impact on the anti-viral host immune responses and potentially viral adaptation across species. This field is still scarcely explored, whilst understanding PTMs is not only important to advance the knowledge of virus pathology but also potentially to provide insights for vaccine development. In this review, we attempt to summarize the latest findings mainly published over the last 10 years, focusing on the roles of PTMs involved in virus infection and anti-viral immune responses, in the context of relevant human respiratory infections: influenza A virus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. We decided to concentrate on these three viruses because they currently represent a global health problem due to recurrent outbreaks and pandemic potential. A deeper characterization of the PTMs may help in understanding virus-host interaction with possible implications on curative strategies. Further, we will report on cutting-edge technologies to study in vitro virus infection in different cellular-based systems. In particular, we describe and discuss the application of 2D and 3D lung organoid cell-culture systems as in vitro models to mimic respiratory environments and to study the PTMs in a controlled setting. Finally, we will discuss the importance of PTMs in the context of next-generation vaccine design, especially for their potential role to offer effective protection against respiratory viruses.

Pagina Web:

https://doi.org/10.3390/ijms262412174

Id prodotto:

148954

Handle IRIS:

11562/1178509

ultima modifica:

4 marzo 2026

Citazione bibliografica:

Ben Khlifa, Emna; Campese, Alessia; Corsi, Andrea; Bombieri, Cristina; Romanelli, Maria Grazia; Valenti, Maria Teresa; Zipeto, Donato; Castelli, Matteo; Lievens, Patricia Marie-Jeanne; Ruggiero, Alessandra, Post-Translational Modifications in Respiratory Virus Infection: Recent Insights into the Development of In Vitro Models «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 26 , n. 24 , 2025 , pp. 1-20

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo