Pubblicazioni

Autori:

Lando, Valentina; Calciano, Lucia; Minelli, Cosetta; Bombieri, Cristina; Ferrari, Marcello; Malerba, Giovanni; Margagliotti, Antonino; Murgia, Nicola; Nicolis, Morena; Olivieri, Mario; Potts, James; Tardivo, Stefano; Accordini, Simone

Titolo:

IL18 gene polymorphism is associated with total IgE in adult subjects with asthma

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

JOURNAL OF CLINICAL MEDICINE

ISSN Rivista:

2077-0383

N° Volume:

12

Numero o Fascicolo:

12

Intervallo pagine:

1-13

Parole chiave:

IL18; SNP; asthma; biomarker; polymorphism; total IgE

Breve descrizione dei contenuti:

The allergic asthma phenotype is characterized by a T helper type 2 (Th2) immune response, based on Immunoglobulin E (IgE)-mediated type 1 hypersensitivity reactions. Total IgE is the sum of all IgE types produced by the human body and is used as a biomarker of inflammation in asthma. We analysed data collected in 143 asthma cases (median age 42.1 years) from the general Italian population (GEIRD survey; 2008-2010) to identify single nucleotide polymorphisms (SNPs) in candidate genes that are associated with total IgE in adult subjects with asthma. These patients reported respiratory symptoms in response to perennial allergens and provided data on 166 SNPs tagging 50 candidate genes or gene regions. Replication of the statistically significant results was performed in 842 asthma cases from other European countries (ECRHS II survey; 1998-2002). SNP rs549908 in interleukin 18 (IL18) gene was significantly associated with total IgE in GEIRD, and this result was replicated in ECRHS II. SNP rs1063320 in the human leukocyte antigen G (HLA-G) gene was identified in GEIRD, but this association was not replicated in ECRHS II. Further investigating IL18 and its biological pathways could be important for developing new therapeutic targets, due to its involvement in inflammatory response processes.

Pagina Web:

https://doi.org/10.3390/jcm12123963

Id prodotto:

134490

Handle IRIS:

11562/1097827

ultima modifica:

30 giugno 2023

Citazione bibliografica:

Lando, Valentina; Calciano, Lucia; Minelli, Cosetta; Bombieri, Cristina; Ferrari, Marcello; Malerba, Giovanni; Margagliotti, Antonino; Murgia, Nicola; Nicolis, Morena; Olivieri, Mario; Potts, James; Tardivo, Stefano; Accordini, Simone, IL18 gene polymorphism is associated with total IgE in adult subjects with asthma «JOURNAL OF CLINICAL MEDICINE» , vol. 12 , n. 12 , 2023 , pp. 1-13

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