Pubblicazioni

Autori:

Pirazzini, Chiara; Azevedo, Tiago; Baldelli, Luca; Bartoletti-Stella, Anna; Calandra-Buonaura, Giovanna; Dal Molin, Alessandra; Dimitri, Giovanna Maria; Doykov, Ivan; Gómez-Garre, Pilar; Hägg, Sara; Hällqvist, Jenny; Halsband, Claire; Heywood, Wendy; Jesús, Silvia; Jylhävä, Juulia; Kwiatkowska, Katarzyna Malgorzata; Labrador-Espinosa, Miguel A; Licari, Cristina; Maturo, Maria Giovanna; Mengozzi, Giacomo; Meoni, Gaia; Milazzo, Maddalena; Periñán-Tocino, Maria Teresa; Ravaioli, Francesco; Sala, Claudia; Sambati, Luisa; Schade, Sebastian; Schreglmann, Sebastian; Spasov, Simeon; Tenori, Leonardo; Williams, Dylan; Xumerle, Luciano; Zago, Elisa; Bhatia, Kailash P; Capellari, Sabina; Cortelli, Pietro; Garagnani, Paolo; Houlden, Henry; Liò, Pietro; Luchinat, Claudio; Delledonne, Massimo; Mills, Kevin; Mir, Pablo; Mollenhauer, Brit; Nardini, Christine; Pedersen, Nancy L; Provini, Federica; Strom, Stephen; Trenkwalder, Claudia; Turano, Paola; Bacalini, Maria Giulia; Franceschi, Claudio; Astrid, Adarmes-Gómez; Marta, Bonilla-Toribio; Claudia, Boninsegna; Marcella, Broli; Dolores, Buiza-Rueda; Mario, Carrión-Claro; Rosalia, Cilea; Robert, Clayton; Silvia De Luca, ; Patrizia De Massis, ; Rocio, Escuela-Martin; Giovanni, Fabbri; Anna, Gabellini; Cristina, Giuliani; Pietro, Guaraldi; Ismae, Huertas; Daniel, Macias; Stefania, Macrì; Magrinelli, Francesca; Juan Francisco Martín Rodríguez, ; Francesco, Mignani; Stefania Alessandra Nassetti, ; Cesa Lorella Maria Scaglione, ; Cristina, Tejera-Parrado; Franco, Valzania; Rosario Vigo Ortega,

Titolo:

A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

Mechanisms of Ageing and Development

ISSN Rivista:

0047-6374

N° Volume:

194

Numero o Fascicolo:

111426

Intervallo pagine:

1-10

Parole chiave:

Inflammaging; Neurodegeneration; Omics; Parkinson's disease

Breve descrizione dei contenuti:

Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project "PROPAG-AGEING", whose aim is to characterize the contribution of the ageing process to PD development. We summarize current evidences that support the existence of a continuum between ageing and PD and justify the use of a Geroscience approach to study PD. We focus in particular on the role of inflammaging, the chronic, low-grade inflammation characteristic of elderly physiology, which can propagate and transmit both locally and systemically. We then describe PROPAG-AGEING design, which is based on the multi-omic characterization of peripheral samples from clinically characterized drug-naive and advanced PD, PD discordant twins, healthy controls and "super-controls", i.e. centenarians, who never showed clinical signs of motor disability, and their offspring. Omic results are then validated in a large number of samples, including in vitro models of dopaminergic neurons and healthy siblings of PD patients, who are at higher risk of developing PD, with the final aim of identifying the molecular perturbations that can deviate the trajectories of healthy ageing towards PD development.

Pagina Web:

https://doi.org/10.1016/j.mad.2020.111426

Id prodotto:

119505

Handle IRIS:

11562/1037058

ultima modifica:

2 dicembre 2022

Citazione bibliografica:

Pirazzini, Chiara; Azevedo, Tiago; Baldelli, Luca; Bartoletti-Stella, Anna; Calandra-Buonaura, Giovanna; Dal Molin, Alessandra; Dimitri, Giovanna Maria; Doykov, Ivan; Gómez-Garre, Pilar; Hägg, Sara; Hällqvist, Jenny; Halsband, Claire; Heywood, Wendy; Jesús, Silvia; Jylhävä, Juulia; Kwiatkowska, Katarzyna Malgorzata; Labrador-Espinosa, Miguel A; Licari, Cristina; Maturo, Maria Giovanna; Mengozzi, Giacomo; Meoni, Gaia; Milazzo, Maddalena; Periñán-Tocino, Maria Teresa; Ravaioli, Francesco; Sala, Claudia; Sambati, Luisa; Schade, Sebastian; Schreglmann, Sebastian; Spasov, Simeon; Tenori, Leonardo; Williams, Dylan; Xumerle, Luciano; Zago, Elisa; Bhatia, Kailash P; Capellari, Sabina; Cortelli, Pietro; Garagnani, Paolo; Houlden, Henry; Liò, Pietro; Luchinat, Claudio; Delledonne, Massimo; Mills, Kevin; Mir, Pablo; Mollenhauer, Brit; Nardini, Christine; Pedersen, Nancy L; Provini, Federica; Strom, Stephen; Trenkwalder, Claudia; Turano, Paola; Bacalini, Maria Giulia; Franceschi, Claudio; Astrid, Adarmes-Gómez; Marta, Bonilla-Toribio; Claudia, Boninsegna; Marcella, Broli; Dolores, Buiza-Rueda; Mario, Carrión-Claro; Rosalia, Cilea; Robert, Clayton; Silvia De Luca, ; Patrizia De Massis, ; Rocio, Escuela-Martin; Giovanni, Fabbri; Anna, Gabellini; Cristina, Giuliani; Pietro, Guaraldi; Ismae, Huertas; Daniel, Macias; Stefania, Macrì; Magrinelli, Francesca; Juan Francisco Martín Rodríguez, ; Francesco, Mignani; Stefania Alessandra Nassetti, ; Cesa Lorella Maria Scaglione, ; Cristina, Tejera-Parrado; Franco, Valzania; Rosario Vigo Ortega,, A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project «Mechanisms of Ageing and Development» , vol. 194 , n. 111426 , 2021 , pp. 1-10

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