Pubblicazioni

Autori:

Magro, Daniéla Oliveira; Santos, Andrey; Guadagnini, Dioze; de Godoy, Flavia Moreira; Silva, Sylvia Helena Monteiro; Lemos, Wilson José Fernandes; Vitulo, Nicola; Torriani, Sandra; Pinheiro, Lilian Vital; Martinez, Carlos Augusto Real; Saad, Mario José Abdalla; Coy, Claudio Saddy Rodrigues

Titolo:

Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

SCIENTIFIC REPORTS

ISSN Rivista:

2045-2322

N° Volume:

9

Numero o Fascicolo:

1

Intervallo pagine:

1-10

Parole chiave:

Crohn’s disease, microbiome

Breve descrizione dei contenuti:

Previous studies have demonstrated that patients with Crohn's disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses. The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analytical cross-sectional single center study, which recruited 18 CD patients and 18 healthy controls (CG) residing in the same home, meaning that all of the participants experienced the same environmental factors, with similar hygiene status, diet, pollution and other common lifestyle characteristics that may influence the composition of the gut microbiota. When compared to healthy controls, the CD patients exhibited lower microbial et-diversity (p = 0.047), a greater abundance of the Proteobacteria phylum (p = 0.037) and a reduction in the Deltaproteobacteria class (p = 0.0006). There was also a reduction in the Akkermansia (p = 0.002) and Oscillospira (p = 0.024) genera and in the proportion of the yeast Saccharomyces cerevisiae (p = 0.01). Additionally, CD patients in remission presented increased neutral (p = 0.001) and acid mucin (p = 0.002) concentrations. The reductions in the proportions of Oscollospira and Akkermansia genera, sulfate-reducing bacteria and Saccharomyces cerevisiae, observed in the CD group, may account for the increased mucins production observed in these patients.

Id prodotto:

111671

Handle IRIS:

11562/1009021

ultima modifica:

28 novembre 2022

Citazione bibliografica:

Magro, Daniéla Oliveira; Santos, Andrey; Guadagnini, Dioze; de Godoy, Flavia Moreira; Silva, Sylvia Helena Monteiro; Lemos, Wilson José Fernandes; Vitulo, Nicola; Torriani, Sandra; Pinheiro, Lilian Vital; Martinez, Carlos Augusto Real; Saad, Mario José Abdalla; Coy, Claudio Saddy Rodrigues, Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production «SCIENTIFIC REPORTS» , vol. 9 , n. 1 , 2019 , pp. 1-10

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