Global climate change poses new challenges for plant species, including new and complex combinations of environmental conditions to which plants should adjust and adapt. Mediterranean ecosystems are recognized biodiversity hotspots, but are also global climate change hotspots due to the concerted action of multiple environmental drivers. This study aims to provide an improved assessment of the practical adaptation options for the viticulture of Tuscany and of Valpolicella and what could be the strength and resilience to climate change of grapevine varieties in these areas.