The aim of this teaching is to analyze the biochemical process of protein synthesis and to explore the different post-traslational modification and their functions.
The course also analyzes and the structural and molecular aspects of regulatory processes and the evolutionary aspects in protein biosynthasis.
Protein Biosynthesis. The biosynthetic pathway: molecular and evolutionary aspercts. Aminoacyl-tRNA synthases. Regulation of the translational process in eukaryotes. Non-canonical translation.
Post-translational modifications (PTM): covalent modifications, glycosylation and glycoprotein biosynthesis, ADP-ribosylation, covalen binding with lipid molecules, proteolitic cleavage of inactive precursors, protein splicing.
The life of the proteins. Protein targeting. Protein turnover. Protein aging. Proteasome and Caspases.
Power point presentation of research articles concerning a specific aspect of protein synthesis and PTM.
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Italian Fiscal Code 93009870234
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