dominici
univrit
Paola_Dominici CV_Eng
(pdf, en, 217 KB, 11/09/25)
Paola_Dominici CV_ita
(pdf, it, 217 KB, 11/09/25)
My scientific interests are directed to the biochemistry and biophysics of proteins, with particular attention to the studies on the structure, function and evolution of pyridoxal 5'-phosphate (PLP) -dependent enzymes and metallo-proteins.
•Characterization of the stability, catalytic mechanism and specificity of pyridoxal phosphate- dependent enzymes, including DOPA decarboxylase, Glutamic acid decarboxylase, cystathionine beta synthase, ornithine aminotransferase and cystathionine gamma lyase.
•Elucidation of structure-dynamics-function relationships of non-symbiotic plant hemoglobins exploiting biochemical and biophysical methods.
•Calcium sensors (calmodulin and centrins) and the mechanisms by which these proteins regulate complex molecular calcium-dependent processes in different organisms.
•Characterization of enzymatic proteins of pathogens from both eukaryotic (Toxoplasma gondii) and prokaryotic organisms (Pseudomonas aeruginosa). This work primarily focuses on their interaction with pharmaceutical molecules from structural and functional perspectives, aiming to develop effective strategies for combating infections.
•Characterization of enzymes with peptidyl-prolyl isomerase (PPIase) activity. These enzymes belong to the cyclophilin family and play crucial roles in various biological processes (e.g. host invasion and pathogen survival). They are considered pivotal virulence factors, making them attractive drug candidates for the development of new antimicrobial molecules.
Modules running in the period selected: 90.
Click on the module to see the timetable and course details.
Di seguito sono elencati gli eventi e gli insegnamenti di Terza Missione collegati al docente:
| Topic | Description | Research area |
|---|---|---|
| Interazioni proteina-ligando | Studio dei meccanismi molecolari della interazione di ligandi con proteine calcio-sensori ed eme- proteine |
Structural , functional and expression proteomics
Molecular interactions |
| Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates | Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates |
Biochimica e Biologia Molecolare
Macromolecular complexes including interactions involving Nucleic Acids, Proteins, Lipids and Carbohydrates |
| Molecular biophysics, biomechanics, bioenergetics | Molecular biophysics, biomechanics, bioenergetics |
Biochimica e Biologia Molecolare
Molecular biophysics, biomechanics, bioenergetics |
| Proteine ricombinanti ed Ingegneria proteica | Produzione di proteine ricombinanti in sistemi di espressione procariotici. Ingegnerizzazione proteica mediante mutagenesi razionale. |
Structural , functional and expression proteomics
Applied genetic engineering, transgenic organisms, recombinant proteins, biosensors |
| Studio del rapporto struttura/funzione di enzimi | Meccanismi catalitici e regolatori di enzimi piridossal-fosfato-dipendent |
Structural , functional and expression proteomics
General biochemistry and metabolism |
| Office | Collegial Body |
|---|---|
| member | Biotechnology Teaching Committee - Department Biotechnology |
| member | Computer Science Teaching Committee - Department Computer Science |
| member | Innovation and sustainability in the industrial production of food Teaching Committee - Department Biotechnology |
| Molecular and Medical Biotechnology Teaching Committee - Department Biotechnology | |
| full prof. | Biotechnology Departmental Council - Department Biotechnology |
| Componente del CDA | Board of Governors |
| member | Scientific and Technological Department Board |
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