Publications

Authors:

Colavito, Valeria; Tesoriero, Chiara; Wirtu, AMENU TOLERA; Grassi Zucconi, G.; BENTIVOGLIO FALES, Marina

Title:

Limbic thalamus and state-dependent behavior: the paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks.

Year:

2015

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

ISSN of journal:

0149-7634

N° Volume:

54

Page numbers:

3-17

Keyword:

circadian rhythms,clock genes,emotion,fos,hypocretin,light,mood,orexin,reward,sleep,stress,suprachiasmatic nucleus

Short description of contents:

The paraventricular thalamic nucleus (PVT), the main component of the dorsal thalamic midline, receives multiple inputs from the brain stem and hypothalamus, and targets the medial prefrontal cortex, nucleus accumbens and amygdala. PVT has been implicated in several functions, especially adaptation to chronic stress, addiction behaviors and reward, mood, emotion. We here focus on the wiring and neuronal properties linking PVT with circadian timing and sleep/wake regulation, and their behavioral implications. PVT is interconnected with the master circadian pacemaker, the hypothalamic suprachiasmatic nucleus, receives direct and indirect photic input, is densely innervated by orexinergic neurons which play a key role in arousal and state transitions. Endowed with prominent wake-related Fos expression which is suppressed by sleep, and with intrinsic neuronal properties showing a diurnal oscillation unique in the thalamus, PVT could represent a station of interaction of thalamic and hypothalamic sleep/wake-regulatory mechanisms. PVT could thus play a strategic task by funneling into limbic and limbic-related targets circadian timing and state-dependent behavior information, tailoring it for cognitive performance and motivated behaviors.

Web page:

http://dx.doi.org/10.1016/j.neubiorev.2014.11.021

Product ID:

87626

Handle IRIS:

11562/848364

Last Modified:

November 6, 2024

Bibliographic citation:

Colavito, Valeria; Tesoriero, Chiara; Wirtu, AMENU TOLERA; Grassi Zucconi, G.; BENTIVOGLIO FALES, Marina, Limbic thalamus and state-dependent behavior: the paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks. «NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS» , vol. 54 , 2015 , pp. 3-17

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