Seminari - Dipartimento Biotecnologie validi dal 12.03.2026 al 12.03.2027. https://www.dbt.univr.it/?ent=seminario&rss=0 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6939 Relatore: Dott.ssa Francesca Girardi; Provenienza: Quality & Safety System Manager Tecres S.p.A.; Data inizio: 2026-03-20; Ora inizio: 14.30; Note orario: Aula 1.04, Istituti Biologici – Biologico 3; Referente interno: Roberto Fiammengo. Fri, 20 Mar 2026 14:30:00 +0100 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6939 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6932 Relatore: Prof. Dr. Alberto Dal Corso; Provenienza: Università degli Studi di Milano, Dipartimento di Chimica; Data inizio: 2026-03-26; Ora inizio: 16.30; Note orario: Room T.02b-Ca' Vignal3 Borgo Roma; Referente interno: Roberto Fiammengo; Riassunto: Hetero-bifunctional constructs, especially antibody-drug conjugates (ADCs), combine two molecular entities to selectively deliver drugs and improve therapeutic efficacy, and they are now being explored beyond oncology, including autoimmune and infectious diseases. Alongside ADCs, drug conjugates to smaller tumor-targeting ligands (e.g., synthetic small molecules or peptides) are also attracting attention, as they may overcome pharmacokinetic limits of large IgG antibodies, showing faster and more selective tumor accumulation. This lecture will illustrate the pros and cons of antibodies and small molecules as drug delivery carriers, especially describing how aldehyde tags could be generally exploited as electrophilic warheads to engage Lys residues in various protein targets, ideally reducing the binding strength gap between small ligands antibodies. Besides the targeting units, the lecture will describe the state-of-the-art of linker-payload modules, i.e., the fragments devoted to the carrier conjugation to the pharmaceutically active drug and its selective release in the tumor site. Here, the role of self-immolative spacers will be introduced, with focus on pyrrolidine-carbamate constructs and their application to a rapid and efficient release of alcohol-bearing drugs. Thu, 26 Mar 2026 16:30:00 +0100 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6932 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6931 Relatore: Dr. Benoit Couturaud; Provenienza: Université Paris Est Créteil, Institut de Chimie et Matériaux; Data inizio: 2026-03-27; Ora inizio: 10.00; Note orario: Room 1.11 –Edificio Biologico 3, Borgo Roma; Referente interno: Roberto Fiammengo; Riassunto: Self-assembly and macromolecular engineering are rapidly growing fields of research, offering promising prospects for the formulation of novel colloidal systems with biomedical applications. This presentation provides an exploration of these themes, highlighting recent advancements, challenges encountered, and future perspectives based on the work conducted in my group. Our research primarily focuses on Polymerization-Induced Self-Assembly (PISA) for the synthesis of nanoparticles designed for drug delivery. Key developments include improvements in encapsulation methods, the creation of stimuli-responsive particles, and the use of degradable polymers for targeted biomedical applications. Finally, we are investigating future directions, including polycondensation-induced self-assembly (McPISA) for the synthesis of polypeptoids based particles. These innovations are set to expand the possibilities of self-assembly and macromolecular engineering while addressing current environmental and industrial challenges. Fri, 27 Mar 2026 10:00:00 +0100 https://www.dbt.univr.it/?ent=seminario&rss=0&id=6931