Publications

Authors:

Tactacan, Carole M; Chang, David K; Cowley, Mark J; Humphrey, Emily S; Wu, Jianmin; Gill, Anthony J; Chou, Angela; Nones, Katia; Grimmond, Sean M; Sutherland, Robert L; Biankin, Andrew V; Daly, Roger J; Biankin, Av; Johns, Al; Mawson, A; Chang, Dk; Scarlett, Cj; Brancato, Ma; Rowe, Sj; Simpson, Sl; Martyn-Smith, M; Chantrill, La; Chin, Vt; Chou, A; Cowley, Mj; Caplan, W; Humphris, Jl; Jones, Md; Mead, R; Nagrial, Am; Pajic, M; Pettit, J; Pinese, M; Rooman, I; Wu, Jun; Daly, Rj; Musgrove, Ea; Sutherland, Rl; Grimmond, Sm; Waddell, N; Kassahn, Ks; Miller, Dk; Wilson, Pj; Patch, Am; Song, S; Harliwong, I; Idrisoglu, S; Nourse, C; Nourbakhsh, E; Manning, S; Wani, S; Gongora, M; Anderson, Michela; Holmes, O; Leonard, C; Taylor, D; Wood, JOHN STEPHAN; Xu, C; Nones, K; Fink, Julika; Christ, A; Bruxner, T; Cloonan, N; Newell, F; Pearson, Jv; Samra, Js; Gill, Aj; Nickpavlakis, ; Guminski, A; Toon, C; Biankin, Av; Asghari, R; Merrett, Nd; Chang, Dk; Pavey, Da; Das, A; Cosman, Ph; Ismail, K; O'Connor, C; Lam, Vw; Mcleod, D; Pleass, Hc; James, V; Kench, Jg; Cooper, Cl; Joseph, D; Sandroussi, C; Crawford, M; Texler, M; Forrest, C; Laycock, A; Epari, Kp; Ballal, M; Fletcher, Dr; Mukhedkar, S; Spry, Na; Deboer, B; Chai, M; Feeney, K; Zeps, N; Beilin, M; Nguyen, Nq; Ruszkiewicz, Ar; Worthley, C; Tan, Cp; Debrencini, T; Chen, J; Brooke-Smith, Me; Papangelis, V; Tang, H; Barbour, Ap; Clouston, Ad; Martin, P; O'Rourke, Tj; Chiang, A; Fawcett, Jw; Slater, K; Yeung, S; Hatzifotis, M; Hodgkinson, P; Christophi, C; Nikfarjam, M; Eshleman, Jr; Hruban, Rh; Maitra, A; Iacobuzio-Donahue, Ca; Schulick, Rd; Wolfgang, Cl; Morgan, Ra; Scarpa, A; Lawlor, Rt; Beghelli, S; Corbo, V; Scardoni, M; Bassi, C; Tempero, Ma.

Title:

RON is not a prognostic marker for resectable pancreatic cancer

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

BMC CANCER

ISSN of journal:

1471-2407

N° Volume:

12

Number or Folder:

1

Page numbers:

395-395

Keyword:

Receptor tyrosine kinase; Biomarker; Gemcitabine; Chemotherapy; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Pancreatic Neoplasms; Prognosis; Proportional Hazards Models; Receptor Protein-Tyrosine Kinases; Tissue Array Analysis

Short description of contents:

Background: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.Methods: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.Results: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.Conclusions: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.

Product ID:

101927

Handle IRIS:

11562/977219

Last Modified:

November 16, 2022

Bibliographic citation:

Tactacan, Carole M; Chang, David K; Cowley, Mark J; Humphrey, Emily S; Wu, Jianmin; Gill, Anthony J; Chou, Angela; Nones, Katia; Grimmond, Sean M; Sutherland, Robert L; Biankin, Andrew V; Daly, Roger J; Biankin, Av; Johns, Al; Mawson, A; Chang, Dk; Scarlett, Cj; Brancato, Ma; Rowe, Sj; Simpson, Sl; Martyn-Smith, M; Chantrill, La; Chin, Vt; Chou, A; Cowley, Mj; Caplan, W; Humphris, Jl; Jones, Md; Mead, R; Nagrial, Am; Pajic, M; Pettit, J; Pinese, M; Rooman, I; Wu, Jun; Daly, Rj; Musgrove, Ea; Sutherland, Rl; Grimmond, Sm; Waddell, N; Kassahn, Ks; Miller, Dk; Wilson, Pj; Patch, Am; Song, S; Harliwong, I; Idrisoglu, S; Nourse, C; Nourbakhsh, E; Manning, S; Wani, S; Gongora, M; Anderson, Michela; Holmes, O; Leonard, C; Taylor, D; Wood, JOHN STEPHAN; Xu, C; Nones, K; Fink, Julika; Christ, A; Bruxner, T; Cloonan, N; Newell, F; Pearson, Jv; Samra, Js; Gill, Aj; Nickpavlakis, ; Guminski, A; Toon, C; Biankin, Av; Asghari, R; Merrett, Nd; Chang, Dk; Pavey, Da; Das, A; Cosman, Ph; Ismail, K; O'Connor, C; Lam, Vw; Mcleod, D; Pleass, Hc; James, V; Kench, Jg; Cooper, Cl; Joseph, D; Sandroussi, C; Crawford, M; Texler, M; Forrest, C; Laycock, A; Epari, Kp; Ballal, M; Fletcher, Dr; Mukhedkar, S; Spry, Na; Deboer, B; Chai, M; Feeney, K; Zeps, N; Beilin, M; Nguyen, Nq; Ruszkiewicz, Ar; Worthley, C; Tan, Cp; Debrencini, T; Chen, J; Brooke-Smith, Me; Papangelis, V; Tang, H; Barbour, Ap; Clouston, Ad; Martin, P; O'Rourke, Tj; Chiang, A; Fawcett, Jw; Slater, K; Yeung, S; Hatzifotis, M; Hodgkinson, P; Christophi, C; Nikfarjam, M; Eshleman, Jr; Hruban, Rh; Maitra, A; Iacobuzio-Donahue, Ca; Schulick, Rd; Wolfgang, Cl; Morgan, Ra; Scarpa, A; Lawlor, Rt; Beghelli, S; Corbo, V; Scardoni, M; Bassi, C; Tempero, Ma., RON is not a prognostic marker for resectable pancreatic cancer «BMC CANCER» , vol. 12 , n. 1 , 2012 , pp. 395-395

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo