Pubblicazioni

RON is not a prognostic marker for resectable pancreatic cancer  (2012)

Autori:
Tactacan, Carole M; Chang, David K; Cowley, Mark J; Humphrey, Emily S; Wu, Jianmin; Gill, Anthony J; Chou, Angela; Nones, Katia; Grimmond, Sean M; Sutherland, Robert L; Biankin, Andrew V; Daly, Roger J; Biankin, Av; Johns, Al; Mawson, A; Chang, Dk; Scarlett, Cj; Brancato, Ma; Rowe, Sj; Simpson, Sl; Martyn-Smith, M; Chantrill, La; Chin, Vt; Chou, A; Cowley, Mj; Caplan, W; Humphris, Jl; Jones, Md; Mead, R; Nagrial, Am; Pajic, M; Pettit, J; Pinese, M; Rooman, I; Wu, Jun; Daly, Rj; Musgrove, Ea; Sutherland, Rl; Grimmond, Sm; Waddell, N; Kassahn, Ks; Miller, Dk; Wilson, Pj; Patch, Am; Song, S; Harliwong, I; Idrisoglu, S; Nourse, C; Nourbakhsh, E; Manning, S; Wani, S; Gongora, M; Anderson, Michela; Holmes, O; Leonard, C; Taylor, D; Wood, JOHN STEPHAN; Xu, C; Nones, K; Fink, Julika; Christ, A; Bruxner, T; Cloonan, N; Newell, F; Pearson, Jv; Samra, Js; Gill, Aj; Nickpavlakis, ; Guminski, A; Toon, C; Biankin, Av; Asghari, R; Merrett, Nd; Chang, Dk; Pavey, Da; Das, A; Cosman, Ph; Ismail, K; O'Connor, C; Lam, Vw; Mcleod, D; Pleass, Hc; James, V; Kench, Jg; Cooper, Cl; Joseph, D; Sandroussi, C; Crawford, M; Texler, M; Forrest, C; Laycock, A; Epari, Kp; Ballal, M; Fletcher, Dr; Mukhedkar, S; Spry, Na; Deboer, B; Chai, M; Feeney, K; Zeps, N; Beilin, M; Nguyen, Nq; Ruszkiewicz, Ar; Worthley, C; Tan, Cp; Debrencini, T; Chen, J; Brooke-Smith, Me; Papangelis, V; Tang, H; Barbour, Ap; Clouston, Ad; Martin, P; O'Rourke, Tj; Chiang, A; Fawcett, Jw; Slater, K; Yeung, S; Hatzifotis, M; Hodgkinson, P; Christophi, C; Nikfarjam, M; Eshleman, Jr; Hruban, Rh; Maitra, A; Iacobuzio-Donahue, Ca; Schulick, Rd; Wolfgang, Cl; Morgan, Ra; Scarpa, A; Lawlor, Rt; Beghelli, S; Corbo, V; Scardoni, M; Bassi, C; Tempero, Ma.
Titolo:
RON is not a prognostic marker for resectable pancreatic cancer
Anno:
2012
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
BMC CANCER
ISSN Rivista:
1471-2407
N° Volume:
12
Numero o Fascicolo:
1
Intervallo pagine:
395-395
Parole chiave:
Receptor tyrosine kinase; Biomarker; Gemcitabine; Chemotherapy; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Pancreatic Neoplasms; Prognosis; Proportional Hazards Models; Receptor Protein-Tyrosine Kinases; Tissue Array Analysis
Breve descrizione dei contenuti:
Background: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.Methods: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.Results: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.Conclusions: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
Id prodotto:
101927
Handle IRIS:
11562/977219
ultima modifica:
16 novembre 2022
Citazione bibliografica:
Tactacan, Carole M; Chang, David K; Cowley, Mark J; Humphrey, Emily S; Wu, Jianmin; Gill, Anthony J; Chou, Angela; Nones, Katia; Grimmond, Sean M; Sutherland, Robert L; Biankin, Andrew V; Daly, Roger J; Biankin, Av; Johns, Al; Mawson, A; Chang, Dk; Scarlett, Cj; Brancato, Ma; Rowe, Sj; Simpson, Sl; Martyn-Smith, M; Chantrill, La; Chin, Vt; Chou, A; Cowley, Mj; Caplan, W; Humphris, Jl; Jones, Md; Mead, R; Nagrial, Am; Pajic, M; Pettit, J; Pinese, M; Rooman, I; Wu, Jun; Daly, Rj; Musgrove, Ea; Sutherland, Rl; Grimmond, Sm; Waddell, N; Kassahn, Ks; Miller, Dk; Wilson, Pj; Patch, Am; Song, S; Harliwong, I; Idrisoglu, S; Nourse, C; Nourbakhsh, E; Manning, S; Wani, S; Gongora, M; Anderson, Michela; Holmes, O; Leonard, C; Taylor, D; Wood, JOHN STEPHAN; Xu, C; Nones, K; Fink, Julika; Christ, A; Bruxner, T; Cloonan, N; Newell, F; Pearson, Jv; Samra, Js; Gill, Aj; Nickpavlakis, ; Guminski, A; Toon, C; Biankin, Av; Asghari, R; Merrett, Nd; Chang, Dk; Pavey, Da; Das, A; Cosman, Ph; Ismail, K; O'Connor, C; Lam, Vw; Mcleod, D; Pleass, Hc; James, V; Kench, Jg; Cooper, Cl; Joseph, D; Sandroussi, C; Crawford, M; Texler, M; Forrest, C; Laycock, A; Epari, Kp; Ballal, M; Fletcher, Dr; Mukhedkar, S; Spry, Na; Deboer, B; Chai, M; Feeney, K; Zeps, N; Beilin, M; Nguyen, Nq; Ruszkiewicz, Ar; Worthley, C; Tan, Cp; Debrencini, T; Chen, J; Brooke-Smith, Me; Papangelis, V; Tang, H; Barbour, Ap; Clouston, Ad; Martin, P; O'Rourke, Tj; Chiang, A; Fawcett, Jw; Slater, K; Yeung, S; Hatzifotis, M; Hodgkinson, P; Christophi, C; Nikfarjam, M; Eshleman, Jr; Hruban, Rh; Maitra, A; Iacobuzio-Donahue, Ca; Schulick, Rd; Wolfgang, Cl; Morgan, Ra; Scarpa, A; Lawlor, Rt; Beghelli, S; Corbo, V; Scardoni, M; Bassi, C; Tempero, Ma., RON is not a prognostic marker for resectable pancreatic cancer «BMC CANCER» , vol. 12 , n. 12012pp. 395-395

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