Publications

Authors:

Darra, Elena; Abdel Azeim, S.; Manara, Anna; Shoji, K.; Maréchal, J. D.; Mariotto, Sofia Giovanna; Cavalieri, Elisabetta; Perbellini, Luigi; Pizza, C.; Perahia, D.; Crimi, Massimo; Suzuki, Hisanori

Title:

Insight into the apoptosis-inducing action of alpha-bisabolol towards malignant tumor cells: involvement of lipid rafts and Bid.

Year:

2008

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Archives of Biochemistry and Biophysics

ISSN of journal:

0003-9861

N° Volume:

476

:

Elsevier Science

Page numbers:

113-123

Keyword:

alpha-bisabolol, apoptosis, pancreatic carcinoma cell lines, lipid rafts, Bid, Surface Plasmon Resonance, mitochondria

Short description of contents:

In a precedent report we showed that alpha-bisabolol, a sesquiterpene present widely in the plant kingdom, exerts a rapid and efficient apoptosis-inducing action selectively towards human and murine malignant glioblastoma cell lines through mitochondrial damage. The present study extends these data demonstrating the apoptosis-inducing action of alpha-bisabolol towards highly malignant human pancreatic carcinoma cell lines without affecting human fibroblast viability. The present study further shows the preferential incorporation of alpha-bisabolol to transformed cells through lipid rafts on plasma membranes and, thereafter, direct interaction between alpha-bisabolol and Bid protein, one of pro-apoptotic Bcl-2 family proteins, analyzed either by Surface Plasmon Resonance method or by intrinsic fluorescence measurement. Notions that lipid rafts are rich in plasma membranes of transformed cells and that Bid, richly present in lipid rafts, is deeply involved in lipid transport make highly credible the hypothesis that the molecular mechanism of alpha-bisabolol action may include its capacity to interact with Bid protein.

Web page:

http://www.ncbi.nlm.nih.gov
http://www.sciencedirect.com

Product ID:

46281

Handle IRIS:

11562/321180

Deposited On:

September 11, 2008

Last Modified:

November 14, 2022

Bibliographic citation:

Darra, Elena; Abdel Azeim, S.; Manara, Anna; Shoji, K.; Maréchal, J. D.; Mariotto, Sofia Giovanna; Cavalieri, Elisabetta; Perbellini, Luigi; Pizza, C.; Perahia, D.; Crimi, Massimo; Suzuki, Hisanori, Insight into the apoptosis-inducing action of alpha-bisabolol towards malignant tumor cells: involvement of lipid rafts and Bid. «Archives of Biochemistry and Biophysics» , vol. 476 , 2008 , pp. 113-123

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