Structural dynamics, aggregation and interactions of amyloidogenic proteins

Proposta di tesi

Structural dynamics, aggregation and interactions of amyloidogenic proteins

Garante
Michael Assfalg
Data proposta
1 ottobre 2019
Data scadenza
30 settembre 2021
Corso di studi
Laurea magistrale in Molecular and medical biotechnology

Descrizione

Structural aspects of prototypical amyloidogenic proteins, such as protein Tau (linked to Alzheimer's disease) and alpha-synuclein (associated with Parkinson's disease), aggregation behaviour, conformations, chemical modifications, interactions
Methods:
protein chemistry: cloning, recombinant expression, purification, gel electrophoresis
biophysical techniques (NMR spectroscopy, Circular Dichroism, Dynamic Light scattering, Calorimetry, Atomic force microscopy, Fluorescence spectroscopy)

Aree di ricerca collegate alla proposta
Biological chemistry - Biological chemistry
Molecular interactions - Molecular interactions