The aim of this course is to cover a few general mechanisms of cell damage, giving information useful to understand the development of molecular pathology towards cell, tissue and organism pathology. The course covers the most important examples of damage to sub-cellular structures, particularly to the plasma membrane, describing in some details examples of alterations of transport, adhesion and signal transduction by membrane receptors. Different type of cell necrosis, factors determining regeneration or repair of injured tissues and molecular and cellular basis of reparative reactions and their pathologic consequences are also illustrated.
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