The course aims at giving a general overview on biological features and clinical application of embryonic, fetal and adult stem cells. Hematopoietic stem cell transplantation, bone marrow microenvironment in normal and pathological hematopoiesis and problems related to stem cell-based approaches to regenerative medicine are particularly developed and discussed.
- INTRODUCTION TO STEM CELLS - EMBRIOLOGY and ORGANOGENESIS - EMBRYONIC STEM CELLS (ESCs) and INDUCED PLURIPOTENT STEM CELLS (iPSCs) - HEMATOPOIETIC STEM CELLS (HSCs) - LEUKEMIA STEM CELLS (LSCs) - MESENCHYMAL STROMAL CELLS (MSCs) - STROMA & CANCER - EXTRACELLULAR VESICLES - NOTCH & WNT PATHWAYS - CARDIAC and LUNG STEM CELLS - NEURAL STEM CELLS - GOOD MANUFACTURING PRACTICE
| Author | Title | Publisher | Year | ISBN | Note |
| Robert Lanza & Anthony Atala | Essentials of Stem Cell Biology (Edizione 3) | Elsevier Scienza Publishing Fumetto INC International Concepts | 9780124095038 |
16 lessons, 3 hours each (total: 48 hours):
Final exam:
- single and oral, in English, without differences between attending and non-attending students
- evaluation criteria: the student must demonstrate to know the concepts developed during the course and to be able to discuss the issues related to the technologies used for the clinical use of stem cells.
