The course aims at furnishing the theoretical and technological basis to approach the study of protein functions. The course integrates proteomic strategies, target identification, biochemical interaction analysis, protein arrays, informatics-based interaction prediction to address the investigation of the proteinogenic changes that underlie the disease pathomechanisms, with examples based on selected diseases.
Characteristics of protein, proteomes and proteomics
Proteomic platforms
Bioinformatic interacting networks
Protein arrays
Imaging SPR
Native MS analysis
Protein enrichment methods
Biochemical approaches to protein protein interaction
Identification of new therapeutic targets in breast cancer
All the supporting material (slides and research papers) will be found on the online platform.
The exam aims at evaluating through a 2 hours written test, composed by open questions, the knowledge gained by the student over both the theory and the methodology in the field of functional proteomic investigations.
