Functional proteomics (2017/2018)

Course code
4S003659
Name of lecturer
Alessandra Maria Bossi
Coordinator
Alessandra Maria Bossi
Number of ECTS credits allocated
6
Academic sector
CHIM/01 - ANALYTICAL CHEMISTRY
Language of instruction
English
Period
I sem. dal Oct 2, 2017 al Jan 31, 2018.

Lesson timetable

Go to lesson schedule

Learning outcomes

The course aims at furnishing the theoretical and technological basis to approach the study of protein functions.
The course integrates proteomic strategies, target identification, biochemical interaction analysis, protein arrays, informatics-based interaction prediction to address the investigation of the proteinogenic changes that underlie the disease pathomechanisms, with examples based on selected diseases.

Syllabus

Characteristics of protein, proteomes and proteomics
Proteomic platforms
Bioinformatic interacting networks
Protein arrays
Imaging SPR
Native MS analysis
Protein enrichment methods
Biochemical approaches to protein protein interaction
Crosstalk tumor-microambient
Identification of new therapeutical targets in breast cancer

All the supporting material (slides and research papers) will be found on the online platform.

Reference books
Author Title Publisher Year ISBN Note
Ciborowski P. and Silberring J. Proteomic profiling and analytical chemistry: the crossroads. Elsevier 2013 978-0-444-59378-8

Assessment methods and criteria

The exam is conceived to evaluate the acquisition of the concepts and methodologies addressed at the functional proteome study.
The exam is based on three open questions to be answered in written mode (2 hours time).
Discussion of the replies is always welcomed.

STUDENT MODULE EVALUATION - 2017/2018