Fundamentals of biotechnological processes and plants (2017/2018)

Course code
David Bolzonella
Academic sector
Language of instruction
Teaching is organised as follows:
Activity Credits Period Academic staff Timetable
teoria 5 I sem. David Bolzonella

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laboratorio 1 I sem. David Bolzonella

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Learning outcomes

The course of Fundamentals of Bioprocess Engineering (5+1 CFU) aims at transferring to students the basic fundamentals about transport phenomena (matter, energy and momentum transfer) as well as the methodology for mass and energy balances around bioreactors operating both in batch and continuous mode for industrial production.
The practical aspects will be considered in the lab module (1 CFU).
These aspects are essential basic information for future courses on the same topic at master level.


Main contents of the course of Fundamentals of Bioprocess Engineering (class part) will be:
1. Introduction
The basic elements like the use of units, scheme representations, including P&ID, or some examples of industrial production will be given
2. Fundamentals
Transport phenomena for mass, energy and momentum.
Mass transfer will include a focus on interphase transfer as in the case of oxygen in water. The Oxygen Transfer Efficiency (OTE) will be defined.
Mixing, type of impellers, baffles, mixing time
3. Bioreactors
Different types of bioreactors, discontinuous (batch) and continuous (CSTR, PFR), will be described. The basic equations and the conditions of stable operation will be defined. Different yields will be defined.
4. Bioreactor facilities
The main facilities for the bioreactor, like mixers and correspondent time of mixing and power, aeration and oxygen transfer mechanisms and efficiency will be studied.
Monitoring and control systems based on physical-chemical signals like pH, redox, OD will be described.

Assessment methods and criteria

The final examination will consist of two parts: a written and an oral test.
The written exam will be made of three parts, two numerical exercise and one theoretical open question. After evaluation of the written part an oral exam will be given.
The reports deriving from the lab experiences will be part of the evaluation.