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Course organization
The course has the objective to teach the molecular mechanisms underlying cell and tissue pathology. Mechanisms responsible for damage of the principal sub-cellular compartments will be examined. Special attention will be given to alterations in cell-matrix and cell-cell communication and to physio-pathology of signal transduction, with special emphasis to neoplastic transformation.The impact of reactive processes (inflammation, hemostatic mechanisms) in pathology will be also examined.
- Introduction to mechanisms of diseases: molecular pathology as a unitary mechanism of cell, tissue and organism damage. Localized and systemic diseases. From cell and tissue damage to whole body damage: cardiac insufficiency, edema and shock..
- Classification of diseases and general aspects of causative factors of diseases.
- Alterations of membrane transport: canalopaties.
- Alterations in cell-cell communication: mechanisms of signal transduction by tyrosine kinase receptors, trimeric G-protein coupled receptors and cytoplasmic tyrosine and serin/threonin kinases. Alterations of signal transduction in neoplstic cells.
- Molecular mechanisms of cell adhesion and their alterations in the context of leukocyte recruitment and platelet adhesion/aggregation.
- Cytoskeleton dynamics and regulation of cell migration.
- Phagocytosis and pathogen-host interaction.
- Diseases due to abnormal accumulations within the cell
- Mitochondria pathologies.
- Reactions to vascular damage: mechanisms of hemostasis and thrombo-embolisms.
- Etio-pathogenesis of atherosclerosis
oral examination
accumuli intracell
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Coagulazione ed eziopatogenesi dei tromboembolismi
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Dalla patologia d'organo alla patologia sistemica
(pptx, it, 418 KB, 15/03/12)
Eziologia generale
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eziopatog dell'aterosclerosi
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Introduzione alla patologia molecolare e cellulare
(pptx, it, 5945 KB, 15/03/12)
patol dell'app vacuolare
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Patol della trasd del segnale - 1
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Patol della trasd del segnale - 2
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Patol della trasd del segnale - 3
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Patol della trasd del segnale - 4
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patol della trasd del segnale - 5
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patol della trasd del segnale - 6
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patol del mitocondrio
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Patologia membrana plasmatica -1
(pptx, it, 3135 KB, 16/03/12)
Patologia membrana plasmatica - 2
(pptx, it, 1535 KB, 16/05/12)
Patologie dell'adesione
(pptx, it, 11684 KB, 17/05/12)
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