| Activity | Credits | Period | Academic staff | Timetable |
|---|---|---|---|---|
| Teoria | 5 | II semestre | Marina Bentivoglio, Raffaella Mariotti | |
| Laboratorio | 1 | II semestre | Marina Bentivoglio |
The course is aimed at knowledge on the use of biotechnology in the field of neurosciences, with special reference to the physiopathology of the nervous system, biomolecular and cellular techniques of neurobiological interest, models of neurological disease, therapeutical approaches
Attendance at the lectures is not required but strongly recommended.
- Principles of structural and functional organization of the nervous tissue
- The neurons: components and polarization
- Ligand-receptor activity in neurotransmission and cell membrane signal transduction mechanisms
- Synaptic transmission
- Glial cells (astrocytes, microglia, oligodendroglia, Schwann cells) and intercellular crosstalk in the nervous system
- Neuronal cell death and apoptosis gene regulation
- Blood-brain barrier: mechanisms of regulation, pathological alterations, biotechnological approaches
- Development of the central nervous system, neuronal migration, genetic regulation
- Principles of organization of sensory systems, motor programme, cognitive processing.
- Pathophysiological mechanisms of nervous system disease
- Experimental models of neurological disease
- Fluorescent proteins and their application to the study of the nervous system
- Stem cells, progenitor cells and nervous tissue
- Reparative mechanisms in the nervous system
- Approaches to the study of gene expression in the central nervous system
- In vitro studies and biotechnological approaches
- Gene therapy
- Cell therapy
Oral examination
Recommended textbook: Eric R. Kandel, James H. Schwartz, Thomas M. Jessell: Principi di neuroscienze
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