Structural dynamics, aggregation and interactions of amyloidogenic proteins

theses proposal

Structural dynamics, aggregation and interactions of amyloidogenic proteins

Guarantor
Michael Assfalg
Suggested date
October 1, 2019
Expiry date
September 30, 2021
Study courses
Master's degree in Molecular and Medical Biotechnology

Description

Structural aspects of prototypical amyloidogenic proteins, such as protein Tau (linked to Alzheimer's disease) and alpha-synuclein (associated with Parkinson's disease), aggregation behaviour, conformations, chemical modifications, interactions
Methods:
protein chemistry: cloning, recombinant expression, purification, gel electrophoresis
biophysical techniques (NMR spectroscopy, Circular Dichroism, Dynamic Light scattering, Calorimetry, Atomic force microscopy, Fluorescence spectroscopy)

Research areas connected to the proposal
Biological chemistry - Biological chemistry
Molecular interactions - Molecular interactions