Toxicology and applied pharmacology (2016/2017)

Course code
4S003679
Name of lecturer
Anna Benini
Coordinator
Anna Benini
Number of ECTS credits allocated
6
Academic sector
BIO/15 - PHARMACEUTICAL BIOLOGY
Language of instruction
English
Location
VERONA
Period
I sem. dal Oct 3, 2016 al Jan 31, 2017.

Lesson timetable

I sem.
Day Time Type Place Note
Monday 11:30 AM - 1:30 PM lesson Lecture Hall Auletta Atrio CV1 from Dec 19, 2016  to Jan 30, 2017
Tuesday 11:30 AM - 1:30 PM lesson Lecture Hall Auletta Atrio CV1 from Dec 20, 2016  to Jan 31, 2017
Wednesday 4:30 PM - 6:30 PM lesson Lecture Hall F from Oct 12, 2016  to Jan 31, 2017
Thursday 4:30 PM - 6:30 PM lesson Lecture Hall I from Oct 13, 2016  to Jan 31, 2017
Friday 9:30 AM - 11:30 AM lesson Lecture Hall Auletta Atrio CV1 from Dec 16, 2016  to Jan 27, 2017

Learning outcomes

The aims of the course are:
- introduction to genearal toxicology, mechanisms of action of toxic agents and different classes of drugs
- to study the basic mechanism chracterising toxic effect
- toxic effects of drugs and other chemicals against principals target body organs
At the end students shoul be able to know molecular mechanims of toxic effects, organ toxicity induced by chemicals and/or drugs, toxicity tests

Syllabus

- Introduction to toxicology
- Different toxic effects and influencing factors
- Toxicokinetics and toxicogenomics
- Mechanisms of toxicity
- Individual susceptibility to toxic chemicals
- Organ toxicity: nervous system, hepatic and renal toxicity, pulmonary and cardiac toxicity, toxicity of immune system, skin toxicity
- In vitro toxicology and toxicokinetics
- Mutagenesis and Genotoxicity
- Applied pharmacology: drug toxicity and drug interaction: anti-inflammatory drugs; Cardiovascular medications;
Antihypertensive agents; Antiarrhythmic drugs; Anticoagulant drugs; Lipid-lowering agents; Cholinergic and adrenergic drugs; Antibiotics; Chemotherapeutics and biotechnological agents
In vitro and in vivo toxicity tests (Ames test; Comet tests, ect)

Lessons' slides and other material (scientific papers) will be given to students at the end of each lesson

Reference books
Author Title Publisher Year ISBN Note
C.L. Galli, E. Corsini , M. Marinovich Tossicologia Piccin 2016
W. Balduini, L. G. Costa Tossicologia generale e applicata ai farmaci Edra S.p.a. 2015

Assessment methods and criteria

At the end students shoul know molecular mechanims of toxic effects, organ toxicity induced by chemicals and/or drugs, toxicity tests

Written examination with open questions on all subjects described in the program

STUDENT MODULE EVALUATION - 2016/2017